NUDC

Nuclear distribution gene C homolog (A. nidulans)

PDB rendering based on 2cr0.

Available structures
PDB	2cr0

Identifiers

Symbols

NUDC; HNUDC; MNUDC; NPD011

External IDs

OMIM: 610325 MGI: 106014 HomoloGene: 4812 GeneCards: NUDC Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • Golgi apparatus • cytosol • cytoskeleton • microtubule
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • cytokinesis • nuclear migration • multicellular organismal development • cell proliferation • response to peptide hormone stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
27.23 – 27.27 Mb

Chr 4:
133.09 – 133.1 Mb

PubMed search

[1]

[2]

Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene.^[1]

Interactions

NUDC has been shown to interact with PLK1^[2] and PAFAH1B1.^[3]

References

^ "Entrez Gene: NUDC nuclear distribution gene C homolog (A. nidulans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10726.
^ Zhou, Tianhua; Aumais Jonathan P, Liu Xiaoqi, Yu-Lee Li-Yuan, Erikson Raymond L (Jul. 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Dev. Cell (United States) 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. ISSN 1534-5807. PMID 12852857.
^ Morris, S M; Albrecht U, Reiner O, Eichele G, Yu-Lee L Y (May. 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Curr. Biol. (ENGLAND) 8 (10): 603–6. doi:10.1016/S0960-9822(98)70232-5. ISSN 0960-9822. PMID 9601647.

Morris SM, Albrecht U, Reiner O, et al. (1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC.". Curr. Biol. 8 (10): 603–6. doi:10.1016/S0960-9822(98)70232-5. PMID 9601647.
Miller BA, Zhang MY, Gocke CD, et al. (1999). "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis.". Exp. Hematol. 27 (4): 742–50. doi:10.1016/S0301-472X(98)00074-5. PMID 10210332.
Matsumoto N, Ledbetter DH (1999). "Molecular cloning and characterization of the human NUDC gene.". Hum. Genet. 104 (6): 498–504. doi:10.1007/s004390050994. PMID 10453739.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Aumais JP, Tunstead JR, McNeil RS, et al. (2002). "NudC associates with Lis1 and the dynein motor at the leading pole of neurons.". J. Neurosci. 21 (24): RC187. PMID 11734602.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Aumais JP, Williams SN, Luo W, et al. (2004). "Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis.". J. Cell. Sci. 116 (Pt 10): 1991–2003. doi:10.1242/jcs.00412. PMID 12679384.
Zhou T, Aumais JP, Liu X, et al. (2003). "A role for Plk1 phosphorylation of NudC in cytokinesis.". Dev. Cell 5 (1): 127–38. doi:10.1016/S1534-5807(03)00186-2. PMID 12852857.
Lin SH, Nishino M, Luo W, et al. (2004). "Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein.". Oncogene 23 (14): 2499–506. doi:10.1038/sj.onc.1207343. PMID 14676831.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Pan RM, Yang Y, Wei MX, et al. (2006). "A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl).". J. Cell. Biochem. 96 (4): 741–50. doi:10.1002/jcb.20573. PMID 16088917.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Nishino M, Kurasawa Y, Evans R, et al. (2006). "NudC is required for Plk1 targeting to the kinetochore and chromosome congression.". Curr. Biol. 16 (14): 1414–21. doi:10.1016/j.cub.2006.05.052. PMID 16860740.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

2cr0: Solution structure of nuclear move domain of nuclear distribution gene C

NUDC

Interactions

References

Further reading