NLRP14

NLR family, pyrin domain containing 14
Identifiers
Symbols NLRP14; CLR11.2; GC-LRR; NALP14; NOD5; PAN8
External IDs OMIM: 609665 MGI: 1924108 HomoloGene: 18531 GeneCards: NLRP14 Gene
Orthologs
Species Human Mouse
Entrez 338323 76858
Ensembl ENSG00000158077 ENSMUSG00000016626
UniProt Q86W24 Q6B966
RefSeq (mRNA) NM_176822 NM_001002894.2
RefSeq (protein) NP_789792 NP_001002894.2
Location (UCSC) Chr 11:
7.04 – 7.09 Mb		 Chr 7:
114.31 – 114.34 Mb
PubMed search [1] [2]

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[1] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[2]

References

  1. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. 
  2. ^ Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801. 

Further reading

CARD domain containing
NOD1/NLRC1 • NOD2/NLRC2 • NLRC3 • NLRC4 • NLRC5
Pyrin domain containing
NLRP1 • NLRP2 • NLRP3 • NLRP4 • NLRP5 • NLRP6 • NLRP7 • NLRP8 • NLRP9 • NLRP10 • NLRP11 • NLRP12 • NLRP13 • NLRP14
Apoptosis inhibitory protein
Family member X1