NLRP10

NLR family, pyrin domain containing 10
Identifiers
Symbols NLRP10; CLR11.1; NALP10; NOD8; PAN5; PYNOD
External IDs OMIM609662 MGI2444084 HomoloGene18468 GeneCards: NLRP10 Gene
Orthologs
Species Human Mouse
Entrez 338322 244202
Ensembl ENSG00000182261 ENSMUSG00000049709
UniProt Q86W26 Q8CCN1
RefSeq (mRNA) NM_176821 NM_175532.3
RefSeq (protein) NP_789791 NP_780741.1
Location (UCSC) Chr 11:
7.98 – 7.99 Mb
Chr 7:
116.07 – 116.07 Mb
PubMed search [1] [2]

NLRP10, short for NOD-like receptor family pyrin domain containing 10, is an intracellular protein of mammals that functions in apoptosis and the immune system. It is also known as NALP10, NOD8, PAN5, Pynod, and CLR11.1, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors, although it differs from other NOD-like receptors by lacking the characteristic leucine-rich repeat domain. It is also believed that it helps regulate the inflammatory response. NLRP8 reduces inflammatory and innate immune responses by inhibiting the activity of two proteins associated with the inflammasome; caspase-1 and PYCARD.[1][2]

References

  1. ^ Wang Y, Hasegawa M, Imamura R, et al. (June 2004). "PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1". Int. Immunol. 16 (6): 777–86. doi:10.1093/intimm/dxh081. PMID 15096476. 
  2. ^ Imamura R, Wang Y, Kinoshita T, et al. (May 2010). "Anti-inflammatory activity of PYNOD and its mechanism in humans and mice". J. Immunol. 184 (10): 5874–84. doi:10.4049/jimmunol.0900779. PMID 20393137. 

Further reading