KLRK1
NKG2-D type II integral membrane protein is a protein that in humans is encoded by the KLRK1 gene.[1][2] KLRK1 has also been designated as CD314 (cluster of differentiation 314).
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. D12S2489E is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The first non-coding exon at the 5' end of the D12S2489E transcript is included in the 3' end of the KLRC4 transcript.[3]
References
- ^ Glienke J, Sobanov Y, Brostjan C, Steffens C, Nguyen C, Lehrach H, Hofer E, Francis F (Sep 1998). "The genomic organization of NKG2C, E, F, and D receptor genes in the human natural killer gene complex". Immunogenetics 48 (3): 163–73. doi:10.1007/s002510050420. PMID 9683661.
- ^ Houchins JP, Yabe T, McSherry C, Bach FH (Apr 1991). "DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells". J Exp Med 173 (4): 1017–20. doi:10.1084/jem.173.4.1017. PMC 2190798. PMID 2007850. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190798.
- ^ "Entrez Gene: KLRK1 killer cell lectin-like receptor subfamily K, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22914.
Further reading
- Raulet DH (2003). "Roles of the NKG2D immunoreceptor and its ligands.". Nat. Rev. Immunol. 3 (10): 781–90. doi:10.1038/nri1199. PMID 14523385.
- Lanier LL (2004). "NKG2D.". J. Biol. Regul. Homeost. Agents 17 (4): 338–40. PMID 15065764.
- Coudert JD, Held W (2006). "The role of the NKG2D receptor for tumor immunity.". Semin. Cancer Biol. 16 (5): 333–43. doi:10.1016/j.semcancer.2006.07.008. PMID 16914326.
- Spertini O, Frei PC (1986). "Biophysical properties and morphology of purified antigen associated with non-A, non-B hepatitis.". Med. Microbiol. Immunol. 175 (4): 229–39. doi:10.1007/BF02123731. PMID 2426565.
- Plougastel B, Trowsdale J (1998). "Cloning of NKG2-F, a new member of the NKG2 family of human natural killer cell receptor genes.". Eur. J. Immunol. 27 (11): 2835–9. doi:10.1002/eji.1830271114. PMID 9394807.
- Plougastel B, Trowsdale J (1998). "Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.". Genomics 49 (2): 193–9. doi:10.1006/geno.1997.5197. PMID 9598306.
- Li P, Willie ST, Bauer S, et al. (1999). "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand.". Immunity 10 (5): 577–84. doi:10.1016/S1074-7613(00)80057-6. PMID 10367903.
- Bauer S, Groh V, Wu J, et al. (1999). "Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.". Science 285 (5428): 727–9. doi:10.1126/science.285.5428.727. PMID 10426993.
- Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730–2. doi:10.1126/science.285.5428.730. PMID 10426994.
- Cosman D, Müllberg J, Sutherland CL, et al. (2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.". Immunity 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445.
- Diefenbach A, Jamieson AM, Liu SD, et al. (2001). "Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.". Nat. Immunol. 1 (2): 119–26. doi:10.1038/77793. PMID 11248803.
- Li P, Morris DL, Willcox BE, et al. (2001). "Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA.". Nat. Immunol. 2 (5): 443–51. doi:10.1038/87757. PMID 11323699.
- Shum BP, Flodin LR, Muir DG, et al. (2002). "Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.". J. Immunol. 168 (1): 240–52. PMID 11751968.
- Radaev S, Rostro B, Brooks AG, et al. (2002). "Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.". Immunity 15 (6): 1039–49. doi:10.1016/S1074-7613(01)00241-2. PMID 11754823.
- Sutherland CL, Chalupny NJ, Schooley K, et al. (2002). "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.". J. Immunol. 168 (2): 671–9. PMID 11777960.
- Holmes MA, Li P, Petersdorf EW, Strong RK (2002). "Structural studies of allelic diversity of the MHC class I homolog MIC-B, a stress-inducible ligand for the activating immunoreceptor NKG2D.". J. Immunol. 169 (3): 1395–400. PMID 12133964.
- Groh V, Wu J, Yee C, Spies T (2002). "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.". Nature 419 (6908): 734–8. doi:10.1038/nature01112. PMID 12384702.
- Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150–5. doi:10.1038/ni857. PMID 12426564.
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PDB gallery
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1hyr: CRYSTAL STRUCTURE OF HUMAN MICA IN COMPLEX WITH NATURAL KILLER CELL RECEPTOR NKG2D
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1kcg: NKG2D in complex with ULBP3
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1mpu: Crystal Structure of the free human NKG2D immunoreceptor
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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| 1-50 |
CD1 ( a-c, 1A, 1D, 1E) · CD2 · CD3 ( γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 ( a) · CD9 · CD10 · CD11 ( a, b, c) · CD13 · CD14 · CD15 · CD16 ( A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 ( A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 ( a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 ( a, b, c, d, e, f) · CD50
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| 51-100 |
CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 ( E, L, P) · CD63 · CD64 ( A, B, C) · CD66 ( a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 ( a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 ( a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100
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| 101-150 |
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| 151-200 |
CD151 · CD152 · CD153 · CD154 · CD155 · CD156 ( a, b, c) · CD157 · CD158 ( a, d, e, i, k) · CD159 ( a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 ( a, b) · CD168 · CD169 · CD170 · CD171 · CD172 ( a, b, g) · CD174 · CD177 · CD178 · CD179 ( a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200
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| 201-250 |
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| 251-300 |
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| 301-350 |
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