NFATC1

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

PDB rendering based on 1a66.
Identifiers
Symbols NFATC1; MGC138448; NF-ATC; NFAT2; NFATc
External IDs OMIM: 600489 MGI: 102469 HomoloGene: 32336 GeneCards: NFATC1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4772 18018
Ensembl ENSG00000131196 ENSMUSG00000033016
UniProt O95644 Q8R4E2
RefSeq (mRNA) NM_006162.3 NM_016791
RefSeq (protein) NP_006153.2 NP_058071
Location (UCSC) Chr 18:
77.16 – 77.29 Mb		 Chr 18:
80.8 – 80.91 Mb
PubMed search [1] [2]

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.[1]

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.[2]

Contents

Interactions

NFATC1 has been shown to interact with PIM1.[3]

See also

References

  1. ^ Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jul 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature 369 (6480): 497–502. doi:10.1038/369497a0. PMID 8202141. 
  2. ^ "Entrez Gene: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4772. 
  3. ^ Rainio, Eeva-Marja; Sandholm Jouko, Koskinen Päivi J (Feb. 2002). "Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase". J. Immunol. (United States) 168 (4): 1524–7. ISSN 0022-1767. PMID 11823475. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.