NEU2

Sialidase 2 (cytosolic sialidase)

PDB rendering based on 1snt.
Identifiers
Symbols NEU2; MGC129579; SIAL2
External IDs OMIM605528 MGI1344417 HomoloGene3927 GeneCards: NEU2 Gene
EC number 3.2.1.18
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4759 23956
Ensembl ENSG00000115488 ENSMUSG00000079434
UniProt Q9Y3R4 n/a
RefSeq (mRNA) NM_005383 NM_015750
RefSeq (protein) NP_005374 NP_056565
Location (UCSC) Chr 2:
233.9 – 233.9 Mb
Chr 1:
89.41 – 89.49 Mb
PubMed search [1] [2]

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.[1][2][3]

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.[3]

References

  1. ^ Monti E, Preti A, Rossi E, Ballabio A, Borsani G (Jun 1999). "Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases". Genomics 57 (1): 137–143. doi:10.1006/geno.1999.5749. PMID 10191093. 
  2. ^ Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E (Jan 2004). "Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules". J Biol Chem 279 (5): 3169–3179. doi:10.1074/jbc.M308381200. PMID 14613940. 
  3. ^ a b "Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4759. 

Further reading