NEO1

Neogenin 1

PDB rendering based on 1x5f.

Available structures
PDB	1X5F, 1X5G, 1X5H, 1X5I, 1X5J, 1X5K

Identifiers

Symbols

NEO1; DKFZp547A066; DKFZp547B146; IGDCC2; NGN

External IDs

OMIM: 601907 MGI: 1097159 HomoloGene: 1870 GeneCards: NEO1 Gene

Gene Ontology
Molecular function	• receptor activity • cadherin binding
Cellular component	• nucleus • nucleolus • cytoplasm • Golgi apparatus • plasma membrane • plasma membrane • integral to plasma membrane
Biological process	• cell adhesion • axon guidance • myoblast fusion • muscle cell differentiation • positive regulation of muscle cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
73.34 – 73.6 Mb

Chr 9:
58.72 – 58.88 Mb

PubMed search

[1]

[2]

Neogenin is a protein that in humans is encoded by the NEO1 gene.^[1]^[2]

Interactions

NEO1 has been shown to interact with PTK2.^[3]

References

^ Meyerhardt JA, Look AT, Bigner SH, Fearon ER (Apr 1997). "Identification and characterization of neogenin, a DCC-related gene". Oncogene 14 (10): 1129–36. doi:10.1038/sj.onc.1200935. PMID 9121761.
^ "Entrez Gene: NEO1 neogenin homolog 1 (chicken)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4756.
^ Ren, Xiu-Rong; Ming Guo-Li, Xie Yi, Hong Yan, Sun Dong-Mei, Zhao Zhong-Qiu, Feng Zhu, Wang Qiang, Shim Sangwoo, Chen Zhou-Feng, Song Hong-Jun, Mei Lin, Xiong Wen-Cheng (Nov. 2004). "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. (United States) 7 (11): 1204–12. doi:10.1038/nn1330. ISSN 1097-6256. PMID 15494733.

Vielmetter J, Kayyem JF, Roman JM, Dreyer WJ (1995). "Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer.". J. Cell Biol. 127 (6 Pt 2): 2009–20. doi:10.1083/jcb.127.6.2009. PMC 2120299. PMID 7806578. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120299.
Keino-Masu K, Masu M, Hinck L, et al. (1996). "Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.". Cell 87 (2): 175–85. doi:10.1016/S0092-8674(00)81336-7. PMID 8861902.
Vielmetter J, Chen XN, Miskevich F, et al. (1997). "Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23.". Genomics 41 (3): 414–21. doi:10.1006/geno.1997.4688. PMID 9169140.
Wang H, Copeland NG, Gilbert DJ, et al. (1999). "Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors.". J. Neurosci. 19 (12): 4938–47. PMID 10366627.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Srinivasan K, Strickland P, Valdes A, et al. (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis.". Dev. Cell 4 (3): 371–82. doi:10.1016/S1534-5807(03)00054-6. PMID 12636918.
Ho SM, Lau KM, Mok SC, Syed V (2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells.". Oncogene 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Matsunaga E, Tauszig-Delamasure S, Monnier PP, et al. (2004). "RGM and its receptor neogenin regulate neuronal survival.". Nat. Cell Biol. 6 (8): 749–55. doi:10.1038/ncb1157. PMID 15258591.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ren XR, Ming GL, Xie Y, et al. (2005). "Focal adhesion kinase in netrin-1 signaling.". Nat. Neurosci. 7 (11): 1204–12. doi:10.1038/nn1330. PMID 15494733.
Lee JE, Kim HJ, Bae JY, et al. (2006). "Neogenin expression may be inversely correlated to the tumorigenicity of human breast cancer.". BMC Cancer 5: 154. doi:10.1186/1471-2407-5-154. PMC 1322231. PMID 16324219. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1322231.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.

PDB gallery

1x5f: The solution structure of the first fibronectin type III domain of human Neogenin

1x5g: The solution structure of the second fibronectin type III domain of human Neogenin

1x5h: The solution structure of the third fibronectin type III domain of human Neogenin

1x5i: The solution structure of the fourth fibronectin type III domain of human Neogenin

1x5j: The solution structure of the fifth fibronectin type III domain of human Neogenin

1x5k: The solution structure of the sixth fibronectin type III domain of human Neogenin

NEO1

Interactions

References

Further reading