NEK6

NIMA (never in mitosis gene a)-related kinase 6

Identifiers

NEK6; SID6-1512

External IDs

OMIM: 604884 MGI: 1891638 HomoloGene: 49379 GeneCards: NEK6 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • signal transducer activity • protein binding • ATP binding • kinesin binding • protein kinase binding
Cellular component	• nucleus • cytoplasm
Biological process	• protein phosphorylation • apoptosis • cell cycle • chromosome segregation • mitosis • signal transduction • peptidyl-serine phosphorylation • regulation of mitotic metaphase/anaphase transition • positive regulation of I-kappaB kinase/NF-kappaB cascade • cell division
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
127.02 – 127.12 Mb

Chr 2:
38.37 – 38.44 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase Nek6 is an enzyme that in humans is encoded by the NEK6 gene.^[1]^[2]

The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests that NEKs perform functions similar to those of NIMA.[supplied by OMIM]^[2]

Interactions

NEK6 has been shown to interact with NEK9.^[3]^[4]^[5]

References

^ Li MZ, Yu L, Liu Q, Chu JY, Zhao SY (April 2000). "Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3→q34.11 by radiation hybrid mapping". Cytogenet Cell Genet 87 (3–4): 271–2. doi:10.1159/000015445. PMID 10702691.
^ ^a ^b "Entrez Gene: NEK6 NIMA (never in mitosis gene a)-related kinase 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10783.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
^ Belham, Christopher; Roig Joan, Caldwell Jennifer A, Aoyama Yumi, Kemp Bruce E, Comb Michael, Avruch Joseph (September 2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. (United States) 278 (37): 34897–909. doi:10.1074/jbc.M303663200. ISSN 0021-9258. PMID 12840024.
^ Roig, Joan; Mikhailov Alexei, Belham Christopher, Avruch Joseph (July 2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. (United States) 16 (13): 1640–58. doi:10.1101/gad.972202. ISSN 0890-9369. PMC 186374. PMID 12101123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186374.

Kobayashi T, Cohen P (1999). "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2". Biochem. J. 339 ( Pt 2) (2): 319–28. doi:10.1042/0264-6021:3390319. PMC 1220160. PMID 10191262. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220160.
Kandli M, Feige E, Chen A, et al. (2001). "Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA". Genomics 68 (2): 187–96. doi:10.1006/geno.2000.6293. PMID 10964517.
Belham C, Comb MJ, Avruch J (2001). "Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase". Curr. Biol. 11 (15): 1155–67. doi:10.1016/S0960-9822(01)00369-4. PMID 11516946.
Kimura M, Okano Y (2001). "Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3". Cytogenet. Cell Genet. 94 (1–2): 33–8. doi:10.1159/000048779. PMID 11701951.
Lizcano JM, Deak M, Morrice N, et al. (2002). "Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo". J. Biol. Chem. 277 (31): 27839–49. doi:10.1074/jbc.M202042200. PMID 12023960.
Hashimoto Y, Akita H, Hibino M, et al. (2002). "Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase". Biochem. Biophys. Res. Commun. 293 (2): 753–8. doi:10.1016/S0006-291X(02)00297-8. PMID 12054534.
Roig J, Mikhailov A, Belham C, Avruch J (2002). "Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression". Genes Dev. 16 (13): 1640–58. doi:10.1101/gad.972202. PMC 186374. PMID 12101123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186374.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
Belham C, Roig J, Caldwell JA, et al. (2003). "A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases". J. Biol. Chem. 278 (37): 34897–909. doi:10.1074/jbc.M303663200. PMID 12840024.
Yin MJ, Shao L, Voehringer D, et al. (2004). "The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis". J. Biol. Chem. 278 (52): 52454–60. doi:10.1074/jbc.M308080200. PMID 14563848.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chen J, Li L, Zhang Y, et al. (2006). "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients". Biochem. Biophys. Res. Commun. 341 (4): 1059–65. doi:10.1016/j.bbrc.2005.12.228. PMID 16476580.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Lee EJ, Hyun SH, Chun J, Kang SS (2007). "Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins". Biochem. Biophys. Res. Commun. 358 (3): 783–8. doi:10.1016/j.bbrc.2007.04.203. PMID 17512906.

NEK6

Interactions

References

Further reading