NCOA4

Nuclear receptor coactivator 4
Identifiers
Symbols NCOA4; ARA70; DKFZp762E1112; ELE1; PTC3; RFG
External IDs OMIM: 601984 MGI: 1350932 HomoloGene: 38052 GeneCards: NCOA4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8031 27057
Ensembl ENSG00000138293 ENSMUSG00000056234
UniProt Q13772 n/a
RefSeq (mRNA) NM_001145260.1 NM_001033988
RefSeq (protein) NP_001138732.1 NP_001029160
Location (UCSC) Chr 10:
51.57 – 51.59 Mb		 Chr 14:
32.97 – 32.99 Mb
PubMed search [1] [2]

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]

Contents

Interactions

NCOA4 has been shown to interact with Peroxisome proliferator-activated receptor gamma[4] and Androgen receptor.[2][5][6][7][8][9][10][11][12]

See also

References

  1. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene 9 (2): 509–16. PMID 8290261. 
  2. ^ a b Yeh S, Chang C (July 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proc Natl Acad Sci U S A 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=39278. 
  3. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031. 
  4. ^ Heinlein, C A; Ting H J, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". J. Biol. Chem. (UNITED STATES) 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. ISSN 0021-9258. PMID 10347167. 
  5. ^ Alen, P; Claessens F, Schoenmakers E, Swinnen J V, Verhoeven G, Rombauts W, Peeters B (January1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Mol. Endocrinol. (UNITED STATES) 13 (1): 117–28. doi:10.1210/me.13.1.117. ISSN 0888-8809. PMID 9892017. 
  6. ^ Miyamoto, H; Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. ISSN 0027-8424. PMC 22623. PMID 9636157. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22623. 
  7. ^ Lin, H K; Yeh S, Kang H Y, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (13): 7200–5. doi:10.1073/pnas.121173298. ISSN 0027-8424. PMC 34646. PMID 11404460. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34646. 
  8. ^ Yeh, S; Lin H K, Kang H Y, Thin T H, Lin M F, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. ISSN 0027-8424. PMC 21881. PMID 10318905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21881. 
  9. ^ Zhou, Zhong-xun; He Bin, Hall Susan H, Wilson Elizabeth M, French Frank S (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Mol. Endocrinol. (United States) 16 (2): 287–300. doi:10.1210/me.16.2.287. ISSN 0888-8809. PMID 11818501. 
  10. ^ He, Bin; Minges John T, Lee Lori W, Wilson Elizabeth M (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". J. Biol. Chem. (United States) 277 (12): 10226–35. doi:10.1074/jbc.M111975200. ISSN 0021-9258. PMID 11779876. 
  11. ^ Gao, T; Brantley K, Bolu E, McPhaul M J (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Mol. Endocrinol. (UNITED STATES) 13 (10): 1645–56. doi:10.1210/me.13.10.1645. ISSN 0888-8809. PMID 10517667. 
  12. ^ He, Bin; Wilson Elizabeth M (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. (United States) 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. ISSN 0270-7306. PMC 149467. PMID 12612084. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149467. 

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Coactivators
ARA (54, 55, 70) • BCAS3 • CARM1 • p300-CBP (EP300, CREBBP) • CRTC (1, 2, 3) • DRIP/TRAP • MN1 • PCAF • PNRC (1, 2) • PPARGC (1A, 1B) • TGFB1I1
NCOA1 (SRC-1) • NCOA2 (GRIP1/SRC-2/TIF2) • NCOA3 (AIB/SRC-3/TRAM-1) • NCOA4 (ARA70) • NCOA5 (CIA) • NCOA6 (RAP250) • NCOA7 (ERAP140)
Corepressors
CTBP (1, 2) • Hairless homolog • LCOR • NRIP1 (RIP140) • PELP-1 • RCOR1 • Rb • SIN3A • SIN3B • Tripartite motif family TRIM (24, 28, 33)
NCOR1 • NCOR2 (SMRT)
ATP-dependent remodeling factors
see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)