NARG1

N(alpha)-acetyltransferase 15, NatA auxiliary subunit

Identifiers

NAA15; Ga19; NARG1; NATH; TBDN100

External IDs

OMIM: 608000 MGI: 1922088 HomoloGene: 14211 GeneCards: NAA15 Gene

Gene Ontology
Molecular function	• protein binding • N-acetyltransferase activity • acetyltransferase activity • ribosome binding
Cellular component	• nucleus • transcription factor complex • cytoplasm
Biological process	• angiogenesis • N-terminal protein amino acid acetylation • multicellular organismal development • cell differentiation • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
140.22 – 140.34 Mb

Chr 3:
51.22 – 51.28 Mb

PubMed search

[1]

[2]

NMDA receptor-regulated protein 1 is a protein that in humans is encoded by the NARG1 gene.^[1]^[2]^[3]

This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase.^[3]

References

^ Fluge O, Bruland O, Akslen LA, Varhaug JE, Lillehaug JR (Jul 2002). "NATH, a novel gene overexpressed in papillary thyroid carcinomas". Oncogene 21 (33): 5056–68. doi:10.1038/sj.onc.1205687. PMID 12140756.
^ Choi SC, Chang JY, Han JK (Jul 2001). "A novel Xenopus acetyltransferase with a dynamic expression in early development". Biochem Biophys Res Commun 285 (5): 1338–43. doi:10.1006/bbrc.2001.5300. PMID 11478804.
^ ^a ^b "Entrez Gene: NARG1 NMDA receptor regulated 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80155.

Gendron RL, Good WV, Adams LC, Paradis H (2001). "Suppressed expression of tubedown-1 in retinal neovascularization of proliferative diabetic retinopathy.". Invest. Ophthalmol. Vis. Sci. 42 (12): 3000–7. PMID 11687548.
He YG, Xie YF, Chen Y, et al. (2002). "[Cloning and analysis of a novel gene encoding N-terminal acetyltransferase subunit]". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34 (3): 353–7. PMID 12019451.
Linē A, Stengrēvics A, Slucka Z, et al. (2002). "Serological identification and expression analysis of gastric cancer-associated genes.". Br. J. Cancer 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2375403.
Willis DM, Loewy AP, Charlton-Kachigian N, et al. (2002). "Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex.". J. Biol. Chem. 277 (40): 37280–91. doi:10.1074/jbc.M206482200. PMID 12145306.
Norwitz ER, Xu S, Xu J, et al. (2002). "Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene.". J. Biol. Chem. 277 (40): 37469–78. doi:10.1074/jbc.M206571200. PMID 12145309.
Lee DK, Kim BC, Kim IY, et al. (2002). "The human papilloma virus E7 oncoprotein inhibits transforming growth factor-beta signaling by blocking binding of the Smad complex to its target sequence.". J. Biol. Chem. 277 (41): 38557–64. doi:10.1074/jbc.M206786200. PMID 12145312.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Arnesen T, Anderson D, Baldersheim C, et al. (2005). "Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.". Biochem. J. 386 (Pt 3): 433–43. doi:10.1042/BJ20041071. PMC 1134861. PMID 15496142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134861.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Arnesen T, Gromyko D, Horvli O, et al. (2006). "Expression of N-acetyl transferase human and human Arrest defective 1 proteins in thyroid neoplasms.". Thyroid 15 (10): 1131–6. doi:10.1089/thy.2005.15.1131. PMID 16279846.
Gendron RL, Good WV, Miskiewicz E, et al. (2006). "Tubedown-1 (Tbdn-1) suppression in oxygen-induced retinopathy and in retinopathy of prematurity.". Mol. Vis. 12: 108–16. PMID 16518308.
Arnesen T, Gromyko D, Pendino F, et al. (2006). "Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein N-alpha-acetyltransferase complex.". Oncogene 25 (31): 4350–60. doi:10.1038/sj.onc.1209469. PMID 16518407.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

NARG1

References

Further reading