NARF

For the Native American Rights Fund (NARF), see Native American Rights Fund.
Nuclear prelamin A recognition factor
Identifiers
Symbols NARF; DKFZp434G0420; FLJ10067; IOP2
External IDs OMIM: 605349 MGI: 1914858 HomoloGene: 57048 GeneCards: NARF Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 26502 67608
Ensembl ENSG00000141562 ENSMUSG00000000056
UniProt Q9UHQ1 n/a
RefSeq (mRNA) NM_001038618.2 NM_026272.3
RefSeq (protein) NP_001033707.1 NP_080548.3
Location (UCSC) Chr 17:
80.42 – 80.45 Mb		 Chr 11:
121.1 – 121.12 Mb
PubMed search [1] [2]

Nuclear prelamin A recognition factor, also known as NARF, is a protein which in humans is encoded by the NARF gene.[1][2][3]

Contents

Function

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.[1]

Interactions

NARF has been shown to interact with LMNA.[2]

References

  1. ^ a b "Entrez Gene: NARF nuclear prelamin A recognition factor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26502. 
  2. ^ a b Barton RM, Worman HJ (October 1999). "Prenylated prelamin A interacts with Narf, a novel nuclear protein". J. Biol. Chem. 274 (42): 30008–18. doi:10.1074/jbc.274.42.30008. PMID 10514485. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10514485. 
  3. ^ Hackstein JH (February 2005). "Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions?". Biochem. Soc. Trans. 33 (Pt 1): 47–50. doi:10.1042/BST0330047. PMID 15667261. 

Further reading