N-Myc

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
Identifiers
Symbols MYCN; MODED; N-myc; NMYC; ODED; bHLHe37
External IDs OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4613 18109
Ensembl ENSG00000134323 ENSMUSG00000037169
UniProt P04198 Q3UII1
RefSeq (mRNA) NM_005378.4 NM_008709.3
RefSeq (protein) NP_005369.2 NP_032735.3
Location (UCSC) Chr 2:
16.08 – 16.09 Mb		 Chr 12:
12.94 – 12.95 Mb
PubMed search [1] [2]

V-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian), also known as MYCN, is a protein which in humans is encoded by the MYCN gene.

Contents

Function

This gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA.[1]

Clinical significance

Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.[2]

Interactions

N-Myc has been shown to interact with MAX.[3][4]

N-Myc is also stabilized by Aurora A which protects it from degradation.[5]

See also

References

  1. ^ "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4613. 
  2. ^ Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299. 
  3. ^ Blackwood, E M; Eisenman R N (Mar. 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science (UNITED STATES) 251 (4998): 1211–7. doi:10.1126/science.2006410. ISSN 0036-8075. PMID 2006410. 
  4. ^ FitzGerald, M J; Arsura M, Bellas R E, Yang W, Wu M, Chin L, Mann K K, DePinho R A, Sonenshein G E (Apr. 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene (ENGLAND) 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. ISSN 0950-9232. PMID 10229200. 
  5. ^ Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma Cancer Cell, Volume 15, Issue 1, 6 January 2009, Pages 67-78, Tobias Otto, Sebastian Horn, Markus Brockmann, Ursula Eilers, Lars Schüttrumpf, Nikita Popov, Anna Marie Kenney, Johannes H. Schulte, Roderick Beijersbergen, Holger Christiansen, Bernd Berwanger, Martin Eilers

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.