Mosapride

Mosapride
Systematic (IUPAC) name
(RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)morpholin-2-yl]methyl}benzamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 112885-41-3 N
ATC code None
PubChem CID 119584
IUPHAR ligand 242
ChemSpider 106780 Y
UNII I8MFJ1C0BY Y
KEGG D08236 Y
ChEMBL CHEMBL60889 Y
Chemical data
Formula C21H25ClFN3O3 
Mol. mass 421.893 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist[1] which accelerates gastric emptying and is used for the treatment of acid reflux[2], irritable bowel syndrome and functional dyspepsia.[3]

References

  1. ^ Kato S, Morie T, Yoshida N. Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent. Chemical and Pharmaceutical Bulletin (Tokyo). 1995 Apr;43(4):699-702.
  2. ^ Ruth M, Hamelin B, Rohss K, Lundell L. The effect of mosapride, a novel prokinetic, on acid reflux variables in patients with gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics. 1998 Jan;12(1):35-40.
  3. ^ Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, Omagari K, Takeshima F, Kohno S. Recent insights into digestive motility in functional dyspepsia. Journal of Gastroenterology. 2006 Nov;41(11):1025-40.
Drugs for
functional bowel disorders
Tertiary
amino group
Other
Belladonna and derivatives
(antimuscarinics)

tertiary amines: Atropine • Hyoscyamine

quaternary ammonium compounds: Scopolamine (Butylscopolamine, Methylscopolamine) • Methylatropine • Fentonium • Cimetropium bromide
Propulsives

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte