Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene.[1]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation-induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]
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Mitogen-activated protein kinase 9 has been shown to interact with TOB1,[3] Grb2,[4][5] MAPK8IP2,[6] P53,[7][8] MAPK8IP3[9][10] and MAPK8IP1.[6][11]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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