Cinacalcet

Cinacalcet
Systematic (IUPAC) name
(R)-N-[1-(1-naphthyl)ethyl]-3-
[3-(trifluoromethyl)phenyl]propan-1-amine
Clinical data
AHFS/Drugs.com monograph
MedlinePlus a605004
Licence data EMA:Link, US FDA:link
Pregnancy cat. B3(AU) C(US)
Legal status ℞ Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability 20 to 25%
Increases if taken with food
Protein binding 93 to 97%
Metabolism Hepatic (CYP3A4-, CYP2D6- and CYP1A2-mediated)
Half-life 30 to 40 hours
Excretion Renal (80%) and fecal (15%)
Identifiers
CAS number 226256-56-0 Y
ATC code H05BX01
PubChem CID 156419
DrugBank APRD00872
ChemSpider 137743 Y
UNII UAZ6V7728S Y
KEGG D03504 Y
ChEBI CHEBI:48390 Y
ChEMBL CHEMBL1201284 N
Chemical data
Formula C22H22F3N 
Mol. mass 357.412 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Cinacalcet (INN) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. It is sold by Amgen under the trade name Sensipar in North America and Australia and as Mimpara in Europe. Cinacalcet is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels), a consequence of having end-stage renal disease.[1] Cinacalcet is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma.[2]

Contents

Clinical uses

Cinacalcet is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and hypercalcemia in patients with parathyroid carcinoma.

Synthesis

B.C. Van Wagenen, S.T. Moe, M.F. Balandrin, E.G. DelMar, E.F. Nemeth, U.S. Patent 6,211,244 (2001).

References

  1. ^ Torres PU (2006). "Cinacalcet HCl: a novel treatment for secondary hyperparathyroidism caused by chronic kidney disease". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 16 (3): 253–8. doi:10.1053/j.jrn.2006.04.010. PMID 16825031. 
  2. ^ "Sensipar for Parathyroid Carcinoma". Amgen. 2009. http://www.sensipar.com/Sensipar_for_HPC.html. Retrieved 25 September 2009. 

External links

Parathyroid hormones and analogues
Anti-parathyroid agents
Calcitonin/Elcatonin • Cinacalcet • Vitamin D analogues (Doxercalciferol, Paricalcitol)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)