Mibefradil

Mibefradil

Systematic (IUPAC) name
(1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl) (methyl)amino)ethyl)-6-fluoro-1-isopropyl- 1,2,3,4-tetrahydronaphthalen-2-yl 2-methoxyacetate
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a607007
Pregnancy cat.	?
Legal status	Withdrawn from market
Routes	Oral
Identifiers
CAS number	116644-53-2^Y
ATC code	C08CX01
PubChem	CID 60662
DrugBank	DB01388
UNII	27B90X776A^N
KEGG	D08217^Y
ChEMBL	CHEMBL45816^N
Chemical data
Formula	C₂₉H₃₈F N₃O₃
Mol. mass	495.63 g/mol
N(what is this?) (verify)

Mibefradil (Posicor) is a drug for the treatment of hypertension and chronic angina pectoris. It belongs to a group known as calcium channel blockers.

It is nonselective.^[1]

On June 8, 1998, Roche announced the voluntary withdrawal of the drug from the market,^[2] due to the potential for drug interactions, some of them serious, which may occur when it is taken together with some other medications.

References

^ Bezprozvanny I, Tsien RW (September 1995). "Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)". Mol. Pharmacol. 48 (3): 540–9. PMID 7565636. http://molpharm.aspetjournals.org/cgi/pmidlookup?view=long&pmid=7565636.
^ Letter from Roche Laboratories: http://www.fda.gov/medwatch/SAFETY/1998/poscor.htm

Channel blocker: calcium channel blockers (C08)

Selective

Dihydropyridines ("-dipine")	Amlodipine^# • Aranidipine • Azelnidipine • Barnidipine • Benidipine • Cilnidipine • Clevidipine • Darodipine • Efonidipine • Felodipine • Isradipine • Lacidipine • Manidipine • Lercanidipine • Mepirodipine • Nicardipine • Nifedipine^# • Niludipin • Nilvadipine • Nimodipine • Nisoldipine • Nitrendipine • Oxodipine • Pranidipine • Ryodipine

Phenylalkylamines ("-pamil")	Anipamil • Devapamil • Emopamil • Falipamil • Gallopamil • Norverapamil • Verapamil

1-4 Benzothiazepines ("-tiazem")	Clentiazem • Diltiazem

Non-selective

Bepridil • Fendiline • Lidoflazine • Perhexiline

Other/ungrouped

Amrinone • Anandamide • Azimilide • Bencyclane • Berbamine • Bevantolol • Canadine • Carboxyamidotriazole • Caroverine • Cinnarizine • Conotoxins • Dauricine • Dimeditiapramine • Dotarizine • Enpiperate • Eperisone • Fantofarone • Fasudil • Fenamic acid • Flunarizine • Fostedil • Gabapentin • Lamotrigine • Magnesium sulfate • Manoalide • Mibefradil^‡ • Monatepil • Naftopidil • Niguldipine • Ochratoxin A • Octylonium • Osthol • Pinaverium • Piperidine • Pregabalin • Prenylamine • Risedronic acid • Sesamodil • Stepholidine • Terodiline • Tetrahydropalmatine • Tetrandrine • Tolfenamic acid • Tranilast • TROX-1 • Ziconotide

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

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