| coenzyme-B sulfoethylthiotransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| EC number | 2.8.4.1 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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Methyl-coenzyme M reductase (MCR) is an enzyme that occurs in archaea. This enzyme catalyzes the formation of methane by combining the hydrogen donor coenzyme B and the methyl donor coenzyme M. Via this enzyme, most of the natural gas on earth was produced. Ruminants (e.g. cows) produce methane because their rumens contain methanogenic bacteria that also rely on this enzyme.
The enzyme has two active sites, each occupied by the nickel-containing F430 cofactor.[1] This conversion is symbolically written as:
The IUBMB Enzyme Nomenclature accepted name is coenzyme-B sulfoethylthiotransferase (EC 2.8.4.1).[2]