Mesembrine

Mesembrine
IUPAC name

(3aS,7aR)-3a- (3,4-dimethoxyphenyl)- 1-methyl-2,3,4,5,7,7a- hexahydroindol-6-one
Identifiers
CAS number 468-53-1 Y
PubChem 193296
Jmol-3D images Image 1
Properties
Molecular formula C17H23NO3
Molar mass 289.37 g mol−1
log P 1.1
Supplementary data page
Structure and
properties		 n, εr, etc.
Thermodynamic
data		 Phase behaviour
Solid, liquid, gas
Spectral data UV, IR, NMR, MS
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Mesembrine is an alkaloid present in Sceletium tortuosum.[1] Mesembrine acts as a serotonin reuptake inhibitor. Mesembrine may contribute to the antidepressant effects of kanna. [2]

References

  1. ^ Smith, M. T.; Crouch, N. R.; Gericke, N.; Hirst, M. (1996). "Psychoactive constituents of the genus Sceletium N.E.Br. And other Mesembryanthemaceae: A review". Journal of ethnopharmacology 50 (3): 119–130. doi:10.1016/0378-8741(95)01342-3. PMID 8691846.  edit
  2. ^ Stafford, G. I.; Pedersen, M. E.; Van Staden, J.; Jäger, A. K. (2008). "Review on plants with CNS-effects used in traditional South African medicine against mental diseases". Journal of Ethnopharmacology 119 (3): 513–537. doi:10.1016/j.jep.2008.08.010. PMID 18775771.  edit
PDE1
MMPX • SCH-51866 • Vinpocetine
PDE2
BAY 60-7550 • EHNA
PDE3
Amrinone • Anagrelide • Bucladesine • Cilostamide • Cilostazol • Enoximone • KMUP-1 • Milrinone • Quazinone • RPL-554 • Siguazodan • Trequinsin • Vesnarinone • Zardaverine
PDE4
Arofylline • Cilomilast • CP-80633 • Denbutylline • Drotaverine • Etazolate • Filaminast • Glaucine • HT-0712 • Ibudilast • ICI-63197 • Irsogladine • Luteolin • Mesembrine • Roflumilast • Rolipram • Ro20-1724 • RPL-554 • YM-976
PDE5
Acetildenafil • Aildenafil • Avanafil • Dipyridamole • Icariin • Lodenafil • Mirodenafil • MY-5445 • Nitrosoprodenafil • Sildenafil • Sulfoaildenafil • T-0156 • Tadalafil • Udenafil • Vardenafil
PDE6
PDE7
PDE9
BAY 73-6691 • SCH-51866
PDE10
Nonselective