| Mertansine | |
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Other names
Maytansinoid DM1 |
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| Identifiers | |
| PubChem | 11343137 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C35H48ClN3O10S |
| Molar mass | 738.29 g mol−1 |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Mertansine is a cytotoxic agent also known as DM1. It is a maytansinoid (that is, a derivative of maytansine).[1]
Its patent rights are owned by ImmunoGen Inc.
The following drugs are antibody-drug conjugates combining monoclonal antibodies with mertansine as the cytotoxic component. Mertansine is linked via 4-mercaptovaleric acid.
Mertansine can also be linked via a more complicated structure – 4-(3-mercapto-2,5-dioxo-1-pyrrolidinylmethyl)-cylohexanecarboxylic acid or MCC –, in which case the International Nonproprietary Name of the conjugate is formed with emtansine: