Marinobufagenin

Marinobufagenin
Other names

Marinobufagin, Marinobufagenin
Identifiers
CAS number 470-42-8
PubChem 10104
Jmol-3D images Image 1
Properties
Molecular formula C24H32O5
Molar mass 400.51 g mol−1
Hazards
Main hazards Toxic
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Marinobufagin is a cardiotonic bufadienolide steroid secreted by the toad Bufo rubescens[1] and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis.[2]

References

  1. ^ Cunha Filho GA, Schwartz CA, Resck IS, Murta MM, Lemos SS, Castro MS, Kyaw C, Pires OR Jr, Leite JR, Bloch C Jr, Schwartz EF. Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens. Toxicon. 2005 May;45(6):777-82. PMID 15804527
  2. ^ Fedorova OV, Talan MI, Agalakova NI, Lakatta EG, Bagrov AY. Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension. Circulation. 2002 Mar 5;105(9):1122-7. PMID 11877366
Bacterial toxins
Mycotoxins
Invertebrates
Vertebrates
note: some toxins are produced by lower species and pass through intermediate species

M: TOX

gen / txn

pto

ant
Bufadienolides
Arenobufagin • Bufotalin • Cinobufagin • Marinobufagin
Cardenolides
Ouabain (g-Strophanthin) • k-Strophanthin • Cymarin

M: HRT

anat/phys/devp

noco/cong/tumr, sysi/epon, injr

proc, drug (C1A/1B/1C/1D), blte