In histopathology, a Mallory body, Mallory-Denk body, and Mallory's hyaline, is an inclusion found in the cytoplasm of liver cells.[1]
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Mallory bodies are classically found in the livers of people suffering from alcoholic liver disease and were once thought to be specific for that.
They are most common in alcoholic hepatitis (prevalence of 65%) and alcoholic cirrhosis (prevalence of 51%).[2]
They are a recognized feature of Wilson's disease (25%), primary biliary cirrhosis (24%), non-alcoholic cirrhosis (24%), hepatocellular carcinoma (23%) and morbid obesity (8%), among other conditions.[2]
Mallory bodies are highly eosinophilic and thus appear pink on H&E stain. The bodies themselves are made up of intermediate keratin filament proteins that have been ubiquinated, or bound by other proteins such as heat shock proteins, or p62.
It is named for Frank Burr Mallory. [3]. [2]
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