Macrofilaricide

A macrofilaricide is a chemotherapeutic compound that is active against filarial nematodes. Many nematodes are economically important parasites of human and animal.

An example is ivermectin.^[1]

References

^ Alley WS, van Oortmarssen GJ, Boatin BA et al. (2001). "Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination". BMC Public Health 1: 12. doi:10.1186/1471-2458-1-12. PMC 60995. PMID 11734070. http://www.biomedcentral.com/1471-2458/1/12.

Antiparasitics – Anthelmintics (P02)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole (Triclabendazole^#)

AI	phosphonic acid (Metrifonate)

Other/unknown	quinoline (Praziquantel^#, Oxamniquine^#) • phenol (Bithionol) • thiazole (Niridazole) • arylsulfonate (Stibophen)

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole (Albendazole^#)

Other/unknown	salicylanilide (Niclosamide)^# • aminoacridine (Quinacrine) • butyrophenone (Desaspidin) • chlorophenol (Dichlorophen)

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole (Mebendazole^#, Albendazole^#, Thiabendazole, Fenbendazole, Ciclobendazole, Flubendazole)

Chloride channel	macrolide (Ivermectin^#)

NMDA	tetrahydropyrimidine (Pyrantel^#, Pyrantel pamoate, Oxantel)

Other/unknown	piperazine (Piperazine • Diethylcarbamazine^#) • thiazole (Levamisole^#) • quinolinium (Pyrvinium) • benzylammonium (Bephenium) • naphthalenesulfonate (Suramin^#) • Tribendimidine

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: IFT

helm,arth (acar)

helm, arth (lice), zoon

helm, arth