MYLIP

Myosin regulatory light chain interacting protein

Identifiers

MYLIP; IDOL; MIR

External IDs

OMIM: 610082 MGI: 2388271 HomoloGene: 8309 GeneCards: MYLIP Gene

6.3.2.-

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • cytoskeletal protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular component	• intracellular • cytoplasm • cytoskeleton • extrinsic to membrane
Biological process	• cellular component movement • nervous system development • negative regulation of low-density lipoprotein particle clearance • protein ubiquitination • protein destabilization • regulation of low-density lipoprotein particle receptor catabolic process • cholesterol homeostasis • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
16.13 – 16.15 Mb

Chr 13:
45.49 – 45.51 Mb

PubMed search

[1]

[2]

Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.^[1]

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.^[2]^[3] The expression of IDOL is induced by the sterol-ativated liver X receptor.

Function

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.^[1]

References

^ ^a ^b "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116.
^ Zelcer N, Hong C, Boyadjian R, Tontonoz P (July 2009). "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science 325 (5936): 100–4. doi:10.1126/science.1168974. PMC 2777523. PMID 19520913. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2777523.
^ Lindholm D, Bornhauser BC, Korhonen L (November 2009). "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. doi:10.1007/s00018-009-0127-y. PMID 19688294.

Olsson PA, Korhonen L, Mercer EA, Lindholm D (2000). "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.". J. Biol. Chem. 274 (51): 36288–92. doi:10.1074/jbc.274.51.36288. PMID 10593918.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310934.
Olsson PA, Bornhauser BC, Korhonen L, Lindholm D (2001). "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6.". Biochem. Biophys. Res. Commun. 279 (3): 879–83. doi:10.1006/bbrc.2000.4028. PMID 11162443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Bornhauser BC, Olsson PA, Lindholm D (2003). "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.". J. Biol. Chem. 278 (37): 35412–20. doi:10.1074/jbc.M306271200. PMID 12826659.
Bornhauser BC, Johansson C, Lindholm D (2003). "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.". FEBS Lett. 553 (1-2): 195–9. doi:10.1016/S0014-5793(03)01010-X. PMID 14550572.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=524842.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ohmura-Hoshino M, Matsuki Y, Aoki M, et al. (2006). "Inhibition of MHC class II expression and immune responses by c-MIR.". J. Immunol. 177 (1): 341–54. PMID 16785530.

MYLIP

Function

References

Further reading