MYL4

Myosin, light chain 4, alkali; atrial, embryonic

Identifiers

MYL4; ALC1; AMLC; GT1

External IDs

OMIM: 160770 MGI: 97267 HomoloGene: 20558 GeneCards: MYL4 Gene

Gene Ontology
Molecular function	• actin monomer binding • calcium ion binding • structural constituent of muscle • myosin II heavy chain binding • actin filament binding
Cellular component	• cytosol • muscle myosin complex • myosin complex • A band
Biological process	• regulation of the force of heart contraction • muscle organ development • muscle filament sliding • positive regulation of ATPase activity • cardiac muscle contraction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
45.29 – 45.3 Mb

Chr 11:
104.41 – 104.46 Mb

PubMed search

[1]

[2]

Myosin light chain 4 is a protein that in humans is encoded by the MYL4 gene.^[1]^[2]

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[2]

References

^ Kurabayashi M, Komuro I, Tsuchimochi H, Takaku F, Yazaki Y (Oct 1988). "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones". J Biol Chem 263 (27): 13930–6. PMID 3417683.
^ ^a ^b "Entrez Gene: MYL4 myosin, light chain 4, alkali; atrial, embryonic". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4635.

Rotter M, Zimmerman K, Poustka A, et al. (1991). "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions". Nucleic Acids Res. 19 (7): 1497–504. doi:10.1093/nar/19.7.1497. PMC 333907. PMID 2027757. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=333907.
Seharaseyon J, Bober E, Hsieh CL, et al. (1990). "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location". Genomics 7 (2): 289–93. doi:10.1016/0888-7543(90)90554-8. PMID 2129532.
Zimmermann K, Kautz S, Hajdu G, et al. (1990). "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells". J. Mol. Biol. 211 (3): 505–13. doi:10.1016/0022-2836(90)90261-J. PMID 2308163.
Seidel U, Bober E, Winter B, et al. (1988). "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms". Gene 66 (1): 135–46. doi:10.1016/0378-1119(88)90231-4. PMID 2458299.
Arnold HH, Lohse P, Seidel U, Bober E (1989). "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria". Eur. J. Biochem. 178 (1): 53–60. doi:10.1111/j.1432-1033.1988.tb14428.x. PMID 2849544.
Strohman RC, Micou-Eastwood J, Glass CA, Matsuda R (1983). "Human fetal muscle and cultured myotubes derived from it contain a fetal-specific myosin light chain". Science 221 (4614): 955–7. doi:10.1126/science.6879193. PMID 6879193.
Timson DJ, Trayer IP (1997). "The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex". FEBS Lett. 400 (1): 31–6. doi:10.1016/S0014-5793(96)01314-2. PMID 9000508.
Timson DJ, Trayer HR, Trayer IP (1998). "The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function". Eur. J. Biochem. 255 (3): 654–62. doi:10.1046/j.1432-1327.1998.2550654.x. PMID 9738905.
Timson DJ, Trayer HR, Smith KJ, Trayer IP (1999). "Size and charge requirements for kinetic modulation and actin binding by alkali 1-type myosin essential light chains". J. Biol. Chem. 274 (26): 18271–7. doi:10.1074/jbc.274.26.18271. PMID 10373429.
Morano I (1999). "Tuning the human heart molecular motors by myosin light chains". J. Mol. Med. 77 (7): 544–55. doi:10.1007/s001099900031. PMID 10494800.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Arrell DK, Neverova I, Fraser H, et al. (2001). "Proteomic analysis of pharmacologically preconditioned cardiomyocytes reveals novel phosphorylation of myosin light chain 1". Circ. Res. 89 (6): 480–7. doi:10.1161/hh1801.097240. PMID 11557734.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Abdelaziz AI, Pagel I, Schlegel WP, et al. (2006). Human Atrial Myosin Light Chain 1 Expression Attenuates Heart Failure. "Human atrial myosin light chain 1 expression attenuates heart failure". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 565: 283–92; discussion 92, 405–15. doi:10.1007/0-387-24990-7_21. ISBN 978-0-387-24989-6. PMID 16106982.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.

MYL4

References

Further reading