MYH10

Myosin, heavy chain 10, non-muscle

Identifiers

MYH10; MGC134913; MGC134914; NMMHCB

External IDs

OMIM: 160776 MGI: 1930780 HomoloGene: 55941 GeneCards: MYH10 Gene

Gene Ontology
Molecular function	• microfilament motor activity • nucleotide binding • actin binding • protein binding • calmodulin binding • ATP binding • ATP binding • actin-dependent ATPase activity • ADP binding • actin filament binding
Cellular component	• stress fiber • cytoplasm • spindle • plasma membrane • cell cortex • myosin complex • axon • growth cone • midbody • neuromuscular junction • cleavage furrow • neuronal cell body • dendritic spine
Biological process	• cytokinesis after mitosis • in utero embryonic development • neuron migration • plasma membrane repair • exocytosis • substrate-dependent cell migration, cell extension • nuclear migration • axon guidance • brain development • adult heart development • cell proliferation • regulation of cell shape • fourth ventricle development • lateral ventricle development • third ventricle development • cerebellar Purkinje cell layer development • actin cytoskeleton organization • actin filament-based movement • neuron projection development • neuromuscular process controlling balance • cardiac myofibril assembly • ventricular cardiac muscle cell development • retina development in camera-type eye
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
8.38 – 8.53 Mb

Chr 11:
68.51 – 68.63 Mb

PubMed search

[1]

[2]

Myosin-10 is a protein that in humans is encoded by the MYH10 gene.^[1]^[2]

References

^ Simons M, Wang M, McBride OW, Kawamoto S, Yamakawa K, Gdula D, Adelstein RS, Weir L (Aug 1991). "Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes". Circ Res 69 (2): 530–9. PMID 1860190.
^ "Entrez Gene: MYH10 myosin, heavy chain 10, non-muscle". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4628.

Phillips CL, Yamakawa K, Adelstein RS (1996). "Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.". J. Muscle Res. Cell. Motil. 16 (4): 379–89. doi:10.1007/BF00114503. PMID 7499478.
Strand D, Unger S, Corvi R, et al. (1995). "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.". Oncogene 11 (2): 291–301. PMID 7542763.
Maupin P, Phillips CL, Adelstein RS, Pollard TD (1995). "Differential localization of myosin-II isozymes in human cultured cells and blood cells.". J. Cell. Sci. 107 ( Pt 11): 3077–90. PMID 7699007.
Itoh K, Adelstein RS (1995). "Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B.". J. Biol. Chem. 270 (24): 14533–40. doi:10.1074/jbc.270.24.14533. PMID 7782316.
Aikawa M, Sivam PN, Kuro-o M, et al. (1993). "Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.". Circ. Res. 73 (6): 1000–12. PMID 7916668.
Shoeman RL, Sachse C, Höner B, et al. (1993). "Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin". Am. J. Pathol. 142 (1): 221–30. PMC 1886840. PMID 8424456. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1886840.
Kawamoto S (1996). "Neuron-specific alternative splicing of nonmuscle myosin II heavy chain-B pre-mRNA requires a cis-acting intron sequence". J. Biol. Chem. 271 (30): 17613–6. doi:10.1074/jbc.271.30.17613. PMID 8663598.
Weir L, Chen D (1997). "Characterization of the nonmuscle myosin heavy chain IIB promoter: regulation by E2F". Gene Expr. 6 (1): 45–57. PMID 8931991.
Ford HL, Silver DL, Kachar B, et al. (1998). "Effect of Mts1 on the structure and activity of nonmuscle myosin II". Biochemistry 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Lin VK, Wang D, Lee IL, et al. (2000). "Myosin heavy chain gene expression in normal and hyperplastic human prostate tissue". Prostate 44 (3): 193–203. doi:10.1002/1097-0045(20000801)44:3<193::AID-PROS3>3.0.CO;2-A. PMID 10906735.
Nguyen M, Breckenridge DG, Ducret A, Shore GC (2000). "Caspase-Resistant BAP31 Inhibits Fas-Mediated Apoptotic Membrane Fragmentation and Release of Cytochrome c from Mitochondria". Mol. Cell. Biol. 20 (18): 6731–40. doi:10.1128/MCB.20.18.6731-6740.2000. PMC 86192. PMID 10958671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86192.
Wei Q, Adelstein RS (2000). "Conditional Expression of a Truncated Fragment of Nonmuscle Myosin II-A Alters Cell Shape but Not Cytokinesis in HeLa Cells". Mol. Biol. Cell 11 (10): 3617–27. PMC 15019. PMID 11029059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15019.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wang F, Kovacs M, Hu A, et al. (2003). "Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance". J. Biol. Chem. 278 (30): 27439–48. doi:10.1074/jbc.M302510200. PMID 12704189.
Huang H, Paliouras M, Rambaldi I, et al. (2003). "Nonmuscle Myosin Promotes Cytoplasmic Localization of PBX". Mol. Cell. Biol. 23 (10): 3636–45. doi:10.1128/MCB.23.10.3636-3645.2003. PMC 164772. PMID 12724421. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164772.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Straight AF, Field CM, Mitchison TJ (2005). "Anillin Binds Nonmuscle Myosin II and Regulates the Contractile Ring". Mol. Biol. Cell 16 (1): 193–201. doi:10.1091/mbc.E04-08-0758. PMC 539163. PMID 15496454. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=539163.
Bastian P, Lang K, Niggemann B, et al. (2005). "Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix". Cell. Mol. Life Sci. 62 (1): 65–76. doi:10.1007/s00018-004-4391-6. PMID 15619008.
Nakasawa T, Takahashi M, Matsuzawa F, et al. (2005). "Critical regions for assembly of vertebrate nonmuscle myosin II". Biochemistry 44 (1): 174–83. doi:10.1021/bi048807h. PMID 15628858.

Proteins of the cytoskeleton

Human

Microfilaments
(ABPs)

Myofilament

Actins	A1, A2, B, C1, G1, G2

Myosins	I (MYO1A, MYO1B, MYO1C, MYO1D, MYO1E, MYO1F, MYO1G, MYO1H) · II (MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16) · III (MYO3A, MYO3B) · V (MYO5A, MYO5B, MYO5C) · VI (MYO6) · VII (MYO7A, MYO7B) · IX (MYO9A, MYO9B) · X (MYO10) · XV (MYO15A) · XVIII (MYO18A, MYO18B) · LC (MYL1, MYL2, MYL3, MYL4, MYL5, MYL6, MYL6B, MYL7, MYL9, MYLIP, MYLK, MYLK2, MYLL1)

Other	Tropomodulin (1, 2, 3, 4) · Troponin (T 1 2 3, C 1 2, I 1 2 3) · Tropomyosin (1, 2, 3, 4) Actinin (1, 2, 3, 4) · Arp2/3 complex · actin depolymerizing factors (Cofilin (1, 2) · Destrin) · Gelsolin · Profilin (1, 2) · Titin

Other

Wiskott-Aldrich syndrome protein · Fibrillin · Filamin (FLNA, FLNB, FLNC) · Espin · TRIOBP

IFs

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 (10, 12, 13, 14, 15, 16, 17, 19, 20) · chromosome 12 (18) · none (21) type II/chromosome 12 (1, 2A, 3, 4, 5, 6A, 6B, 7, 8, 9)

Hair keratins (hard alpha-keratins)	type I/chromosome 17 (31, 32, 33A, 33B, 34, 35, 36, 37, 38) type II/chromosome 12 (81, 82, 83, 84, 85, 86)

Ungrouped alpha	chromosome 17 (23, 24, 25, 26, 27, 28, 39, 40) chromosome 12 (71, 72, 73, 74, 75, 76, 77, 78, 79, 80)

Not alpha	Beta-keratin

Type 3

Desmin, GFAP, Peripherin, Vimentin

Type 4

Internexin, Nestin, Neurofilament (NEFL, NEFM, NEFH), Synemin, Syncoilin

Type 5

Lamin A, B

Microtubules/
MAPs

Kinesins	KIF1A, KIF1B, KIF2A, KIF2C, KIF3B, KIF3C, KIF4A, KIF4B, KIF5A, KIF5B, KIF5C, KIF6, KIF7, KIF9, KIF11, KIF12, KIF13A, KIF13B, KIF14, KIF15, KIF16B, KIF17, KIF18A, KIF18B, KIF19, KIF20A, KIF20B, KIF21A, KIF21B, KIF22, KIF23, KIF24, KIF25, KIF26A, KIF26B, KIF27, KIFC1, KIFC2, KIFC3

Dyneins	axonemal: DNAH1, DNAH2, DNAH3, DNAH5, DNAH6, DNAH7, DNAH8, DNAH9, DNAH10, DNAH11, DNAH12, DNAH13, DNAH14, DNAH17, DNAI1, DNAI2, DNALI1, DNAL1, DNAL4 cytoplasmic: DYNC1H1, DYNC2H1, DYNC1I1, DYNC1I2, DYNC1LI1, DYNC1LI2, DYNC2LI1, DYNLL1, DYNLL2, DYNLRB1, DYNLRB2, DYNLT1, DYNLT3

Other	Tau protein · Dynactin (DCTN1) · Tubulins (TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8) · Stathmin · Tektin (TEKT1, TEKT2, TEKT3, TEKT4, TEKT5) · Dynamin (DNM1, DNM2, DNM3)

Catenins

Alpha catenin · Beta catenin (APC) · Plakoglobin (gamma catenin) · Delta catenin · GAN

Membrane

Dystrophin (Dystroglycan) · Utrophin · Ankyrin (ANK1, ANK2, ANK3) · Spectrin (SPTA1, SPTAN1, SPTB, SPTBN1, SPTBN2, SPTBN4, SPTBN5)

Other

plakin (Desmoplakin, Plectin) · Talin (TLN1) · Vinculin · Plakophilin (PKP1, PKP2)

Nonhuman

Major sperm proteins · Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)

see also cytoskeletal defects
B strc: edmb (perx), skel (ctrs), epit, cili, mito, nucl (chro)

MYH10

References

Further reading