MUC6

Mucin 6, oligomeric mucus/gel-forming

Identifiers

MUC6; MUC6 mucin

External IDs

OMIM: 158374 MGI: 2663233 HomoloGene: 18768 GeneCards: MUC6 Gene

Gene Ontology
Molecular function	• extracellular matrix structural constituent
Cellular component	• extracellular region
Biological process	• maintenance of gastrointestinal epithelium
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
1.01 – 1.04 Mb

Chr 7:
148.82 – 148.84 Mb

PubMed search

[1]

[2]

Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene.^[1]

References

^ "Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4588.

Toribara NW, Roberton AM, Ho SB, et al. (1993). "Human gastric mucin. Identification of a unique species by expression cloning.". J. Biol. Chem. 268 (8): 5879–85. PMID 7680650.
Toribara NW, Ho SB, Gum E, et al. (1997). "The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis Of the primary amino acid sequence.". J. Biol. Chem. 272 (26): 16398–403. doi:10.1074/jbc.272.26.16398. PMID 9195947.
Debailleul V, Laine A, Huet G, et al. (1998). "Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs.". J. Biol. Chem. 273 (2): 881–90. doi:10.1074/jbc.273.2.881. PMID 9422745.
Bartman AE, Buisine MP, Aubert JP, et al. (1999). "The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues.". J. Pathol. 186 (4): 398–405. doi:10.1002/(SICI)1096-9896(199812)186:4<398::AID-PATH192>3.0.CO;2-X. PMID 10209489.
Reid CJ, Harris A (1999). "Expression of the MUC 6 mucin gene in development of the human kidney and male genital ducts.". J. Histochem. Cytochem. 47 (6): 817–22. doi:10.1177/002215549904700611. PMID 10330458.
Newton JL, Allen A, Westley BR, May FE (2000). "The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach". Gut 46 (3): 312–20. doi:10.1136/gut.46.3.312. PMC 1727855. PMID 10673290. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1727855.
Nordman H, Davies JR, Lindell G, et al. (2002). "Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution". Biochem. J. 364 (Pt 1): 191–200. PMC 1222561. PMID 11988092. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222561.
Kim GE, Bae HI, Park HU, et al. (2002). "Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas". Gastroenterology 123 (4): 1052–60. doi:10.1053/gast.2002.36018. PMID 12360467.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rousseau K, Byrne C, Kim YS, et al. (2004). "The complete genomic organization of the human MUC6 and MUC2 mucin genes". Genomics 83 (5): 936–9. doi:10.1016/j.ygeno.2003.11.003. PMID 15081123.
Xia HH, Yang Y, Lam SK, et al. (2004). "Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation". J. Clin. Pathol. 57 (8): 861–6. doi:10.1136/jcp.2003.015487. PMC 1770377. PMID 15280409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1770377.
Parry S, Sutton-Smith M, Heal P, et al. (2005). "Evaluation of MUC6 mucin tandem repeats". Biochim. Biophys. Acta 1722 (1): 77–83. doi:10.1016/j.bbagen.2004.11.010. PMID 15716126.
Sakai H, Jinawath A, Yamaoka S, Yuasa Y (2005). "Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors". Biochem. Biophys. Res. Commun. 333 (4): 1254–60. doi:10.1016/j.bbrc.2005.06.037. PMID 15979574.
Morohara K, Tajima Y, Nakao K, et al. (2007). "Gastric and intestinal phenotypic cell marker expressions in gastric differentiated-type carcinomas: association with E-cadherin expression and chromosomal changes". J. Cancer Res. Clin. Oncol. 132 (6): 363–75. doi:10.1007/s00432-005-0062-8. PMID 16447040.
Cozzi PJ, Wang J, Delprado W, et al. (2006). "MUC1, MUC2, MUC4, MUC5AC and MUC6 expression in the progression of prostate cancer". Clin. Exp. Metastasis 22 (7): 565–73. doi:10.1007/s10585-005-5376-z. PMID 16475027.
Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
Zheng H, Takahashi H, Nakajima T, et al. (2007). "MUC6 down-regulation correlates with gastric carcinoma progression and a poor prognosis: an immunohistochemical study with tissue microarrays". J. Cancer Res. Clin. Oncol. 132 (12): 817–23. doi:10.1007/s00432-006-0135-3. PMID 16807756.
Nguyen TV, Janssen M, Gritters P, et al. (2006). "Short mucin 6 alleles are associated with H pylori infection". World J. Gastroenterol. 12 (37): 6021–5. PMID 17009402.
Mino-Kenudson M, Tomita S, Lauwers GY (2007). "Mucin expression in reactive gastropathy: an immunohistochemical analysis". Arch. Pathol. Lab. Med. 131 (1): 86–90. doi:10.1043/1543-2165(2007)131[86:MEIRGA]2.0.CO;2. PMID 17227128.
Burjonrappa SC, Reddimasu S, Nawaz Z, et al. (2007). "Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus". Indian journal of cancer 44 (1): 1–5. doi:10.4103/0019-509X.31160. PMID 17401217.

Protein, glycoconjugate: glycoproteins and glycopeptides

Mucoproteins

Mucin	CD43 · CD164 · MUC1 · MUC2 · MUC3A · MUC3B · MUC4 · MUC5AC · MUC5B · MUC6 · MUC7 · MUC8 · MUC12 · MUC13 · MUC15 · MUC16 · MUC17 · MUC19 · MUC20

Other	Haptoglobin · Intrinsic factor · Orosomucoid · Peptidoglycan · Phytohaemagglutinin · Ovomucin

Proteoglycans

CS/DS	Decorin · Biglycan · Versican

HS/CS	Testican · Perlecan

CS	Chondroitin sulfate proteoglycans: Aggrecan · Neurocan · Brevican · CD44 · CSPG4 · CSPG5 · Platelet factor 4 · Structural maintenance of chromosomes 3

KS	Fibromodulin · Lumican · Keratocan

HS	Syndecan 1

Other

Activin and inhibin · ADAM · Alpha 1-antichymotrypsin · Apolipoprotein H · CD70 · Asialoglycoprotein · Avidin · B-cell activating factor · 4-1BB ligand · Cholesterylester transfer protein · Clusterin · Colony-stimulating factor · Hemopexin · Lactoferrin · Membrane glycoproteins · Myelin protein zero · Osteonectin · Protein C · Protein S · Serum amyloid P component · Sialoglycoprotein (CD43, Glycophorin, Glycophorin C) · Thrombopoietin · Thyroglobulin · Thyroxine-binding proteins · Transcortin · Tumor necrosis factor-alpha · Uteroglobin · Vitronectin

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/i

MUC6

References

Further reading