MSI1

Musashi homolog 1 (Drosophila)

PDB rendering based on 1uaw.

Available structures
PDB	1uaw, 2mss, 2mst

Identifiers

Symbols

MSI1;

External IDs

OMIM: 603328 MGI: 107376 HomoloGene: 55657 GeneCards: MSI1 Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA binding • single-stranded RNA binding • poly(U) RNA binding
Cellular component	• nucleus • cytoplasm • polysome
Biological process	• nervous system development • response to hormone stimulus • epithelial cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
120.78 – 120.81 Mb

Chr 5:
115.88 – 115.91 Mb

PubMed search

[1]

[2]

RNA-binding protein Musashi homolog 1 is a protein that in humans is encoded by the MSI1 gene.^[1]^[2]

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.^[2]

References

^ Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H (Dec 1998). "The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells". Genomics 52 (3): 382–4. doi:10.1006/geno.1998.5456. PMID 9790759.
^ ^a ^b "Entrez Gene: MSI1 musashi homolog 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4440.

Okano H, Imai T, Okabe M (2002). "Musashi: a translational regulator of cell fate.". J. Cell. Sci. 115 (Pt 7): 1355–9. PMID 11896183.
Toda M, Iizuka Y, Yu W, et al. (2001). "Expression of the neural RNA-binding protein Musashi1 in human gliomas.". Glia 34 (1): 1–7. doi:10.1002/glia.1034. PMID 11284014.
Imai T, Tokunaga A, Yoshida T, et al. (2001). "The Neural RNA-Binding Protein Musashi1 Translationally Regulates Mammalian numb Gene Expression by Interacting with Its mRNA". Mol. Cell. Biol. 21 (12): 3888–900. doi:10.1128/MCB.21.12.3888-3900.2001. PMC 87052. PMID 11359897. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87052.
Sakakibara S, Nakamura Y, Satoh H, Okano H (2001). "Rna-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS". J. Neurosci. 21 (20): 8091–107. PMID 11588182.
Kanemura Y, Mori K, Sakakibara S, et al. (2002). "Musashi1, an evolutionarily conserved neural RNA-binding protein, is a versatile marker of human glioma cells in determining their cellular origin, malignancy, and proliferative activity". Differentiation 68 (2–3): 141–52. doi:10.1046/j.1432-0436.2001.680208.x. PMID 11686236.
Kanemura Y, Sakakibara S, Okano H (2002). "Identification of Musashi1-positive cells in human normal and neoplastic neuroepithelial tissues by immunohistochemical methods". Methods Mol. Biol. 198: 273–81. doi:10.1385/1-59259-186-8:273. ISBN 1-59259-186-8. PMID 11951628.
Shu HJ, Saito T, Watanabe H, et al. (2002). "Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines". Biochem. Biophys. Res. Commun. 293 (1): 150–4. doi:10.1016/S0006-291X(02)00175-4. PMID 12054577.
Miyanoiri Y, Kobayashi H, Imai T, et al. (2003). "Origin of higher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics". J. Biol. Chem. 278 (42): 41309–15. doi:10.1074/jbc.M306210200. PMID 12907678.
Nishimura S, Wakabayashi N, Toyoda K, et al. (2003). "Expression of Musashi-1 in human normal colon crypt cells: a possible stem cell marker of human colon epithelium". Dig. Dis. Sci. 48 (8): 1523–9. doi:10.1023/A:1024763723240. PMID 12924647.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Lovell MA, Markesbery WR (2005). "Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease". J. Neuropathol. Exp. Neurol. 64 (8): 675–80. doi:10.1097/01.jnen.0000173891.17176.5b. PMID 16106215.
Battelli C, Nikopoulos GN, Mitchell JG, Verdi JM (2006). "The RNA-binding protein Musashi-1 regulates neural development through the translational repression of p21WAF-1". Mol. Cell. Neurosci. 31 (1): 85–96. doi:10.1016/j.mcn.2005.09.003. PMID 16214366.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
Chan C, Moore BE, Cotman CW, et al. (2006). "Musashi1 antigen expression in human fetal germinal matrix development". Exp. Neurol. 201 (2): 515–8. doi:10.1016/j.expneurol.2006.04.023. PMID 16777095.

PDB gallery

1uaw: Solution structure of the N-terminal RNA-binding domain of mouse Musashi1

2mss: MUSASHI1 RBD2, NMR

2mst: MUSASHI1 RBD2, NMR

MSI1

References

Further reading