| Mitochondrial ribosomal protein L23 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MRPL23; FLJ45387; L23MRP; RPL23; RPL23L | ||||||||||||
| External IDs | OMIM: 600789 MGI: 1196612 HomoloGene: 7922 GeneCards: MRPL23 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6150 | 19935 | |||||||||||
| Ensembl | ENSG00000214026 | ENSMUSG00000037772 | |||||||||||
| UniProt | Q16540 | Q8CHW3 | |||||||||||
| RefSeq (mRNA) | NM_021134 | NM_011288.1 | |||||||||||
| RefSeq (protein) | NP_066957 | NP_035418.1 | |||||||||||
| Location (UCSC) | Chr 11: 1.97 – 2.01 Mb |
Chr 7: 142.34 – 142.35 Mb |
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| PubMed search | [1] | [2] | |||||||||||
39S ribosomal protein L23, mitochondrial is a protein that in humans is encoded by the MRPL23 gene.[1][2]
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11.[2]