MPHOSPH1

Kinesin family member 20B

Identifiers

KIF20B; CT90; DKFZp434B0435; DKFZp434P0810; KRMP1; MPHOSPH1; MPP-1; MPP1

External IDs

OMIM: 605498 MGI: 2444576 HomoloGene: 9418 GeneCards: KIF20B Gene

Gene Ontology
Molecular function	• nucleotide binding • microtubule motor activity • ATP binding • ATPase activity • WW domain binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • centrosome • spindle • cytoskeleton • microtubule
Biological process	• M phase of mitotic cell cycle • ATP catabolic process • microtubule-based movement • cell cycle • cell cycle arrest • regulation of mitosis • cell division
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000138182

ENSMUSG00000024795

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
91.46 – 91.53 Mb

Chr 19:
35 – 35.05 Mb

PubMed search

Kinesin-like protein KIF20B is a protein that in humans is encoded by the KIF20B gene.^[1]^[2]^[3]^[4]

Interactions

MPHOSPH1 has been shown to interact with PIN1.^[3]

References

^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (Jan 1997). "Identification of novel M phase phosphoproteins by expression cloning". Mol Biol Cell 7 (9): 1455–69. PMC 275994. PMID 8885239. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275994.
^ Westendorf JM, Rao PN, Gerace L (Feb 1994). "Cloning of cDNAs for M-phase phosphoproteins recognized by the MPM2 monoclonal antibody and determination of the phosphorylated epitope". Proc Natl Acad Sci U S A 91 (2): 714–8. doi:10.1073/pnas.91.2.714. PMC 43019. PMID 8290587. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=43019.
^ ^a ^b Kamimoto T, Zama T, Aoki R, Muro Y, Hagiwara M (Oct 2001). "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1". J Biol Chem 276 (40): 37520–8. doi:10.1074/jbc.M106207200. PMID 11470801.
^ "Entrez Gene: MPHOSPH1 M-phase phosphoprotein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9585.

Further reading

Fritzler MJ, Kerfoot SM, Feasby TE, et al. (2000). "Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1)". J. Investig. Med. 48 (1): 28–39. PMID 10695267.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Abaza A, Soleilhac JM, Westendorf J, et al. (2003). "M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis". J. Biol. Chem. 278 (30): 27844–52. doi:10.1074/jbc.M304522200. PMC 2652640. PMID 12740395. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2652640.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.