Methylnitronitrosoguanidine

Methylnitronitrosoguanidine[1]
Identifiers
Abbreviations MNNG
CAS number 70-25-7 Y
PubChem 9562060
KEGG C14592 Y
Jmol-3D images Image 1
Properties
Molecular formula C2H5N5O3
Molar mass 147.09 g/mol
Appearance Yellow crystals
Melting point

118 °C (dec.)

Solubility in water reacts violently, slowly hydrolysed
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Methylnitronitrosoguanidine (MNNG) is a biochemical tool used experimentally as a carcinogen and mutagen.[1] It acts by adding alkyl groups to the O6 of guanine and O4 of thymine. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.

In organic chemistry, MNNG is used as a source of diazomethane when reacted with aqueous potassium hydroxide.[2]

MNNG is a probable human carcinogen listed as an IARC Group 2A carcinogen.[3]

References