MAP2K5

Mitogen-activated protein kinase kinase 5

PDB rendering based on 1wi0.
Identifiers
Symbols MAP2K5; HsT17454; MAPKK5; MEK5; PRKMK5
External IDs OMIM: 602520 MGI: 1346345 HomoloGene: 115933 GeneCards: MAP2K5 Gene
EC number 2.7.12.2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5607 23938
Ensembl ENSG00000137764 ENSMUSG00000058444
UniProt Q13163 Q3TM51
RefSeq (mRNA) NM_001206804.1 NM_011840.2
RefSeq (protein) NP_001193733.1 NP_035970.1
Location (UCSC) Chr 15:
67.84 – 68.12 Mb		 Chr 9:
63.01 – 63.23 Mb
PubMed search [1] [2]

Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene.[1][2]

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.[2]

Contents

Upstream

This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream

This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions

MAP2K5 has been shown to interact with MAPK7,[1] MAP3K2,[3] Protein kinase Mζ[4] and MAP3K3.[3][5]

References

  1. ^ a b Zhou G, Bao ZQ, Dixon JE (Jun 1995). "Components of a new human protein kinase signal transduction pathway". J Biol Chem 270 (21): 12665–9. doi:10.1074/jbc.270.21.12665. PMID 7759517. 
  2. ^ a b "Entrez Gene: MAP2K5 mitogen-activated protein kinase kinase 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5607. 
  3. ^ a b Sun, W; Kesavan K, Schaefer B C, Garrington T P, Ware M, Johnson N L, Gelfand E W, Johnson G L (Feb. 2001). "MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway". J. Biol. Chem. (United States) 276 (7): 5093–100. doi:10.1074/jbc.M003719200. ISSN 0021-9258. PMID 11073940. 
  4. ^ Diaz-Meco, M T; Moscat J (Feb. 2001). "MEK5, a New Target of the Atypical Protein Kinase C Isoforms in Mitogenic Signaling". Mol. Cell. Biol. (United States) 21 (4): 1218–27. doi:10.1128/MCB.21.4.1218-1227.2001. ISSN 0270-7306. PMC 99575. PMID 11158308. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99575. 
  5. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 

Further reading