L 663536

L 663536
IUPAC name

3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2,2 -dimethyl-propanoic acid
Other names

MK 886
Identifiers
CAS number 118414-82-7
PubChem 105049
MeSH L+663536
Properties
Molecular formula C27H34ClNO2S
Molar mass 472.083
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

L 663536 is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX),[1] and may help in treating atherosclerosis.[2]

References

  1. ^ Jun, Joon-Il; Lau, Lester F. (July 2010). "The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing". Nature Cell Biology 12 (7): 676–685. doi:10.1038/ncb2070. ISSN 1465-7392. PMC 2919364. PMID 20526329. http://www.nature.com/ncb/journal/v12/n7/full/ncb2070.html. Retrieved 2011-08-28. 
  2. ^ Jawien, J.; Gajda, M.; Rudling, M.; Mateuszuk, L.; Olszanecki, R.; Guzik, T. J.; Cichocki, T.; Chlopicki, S. et al. (March 2006). "Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice". European Journal of Clinical Investigation 36 (3): 141–146. doi:10.1111/j.1365-2362.2006.01606.x. PMID 16506957.