MIZF

Histone H4 transcription factor

Identifiers

HINFP; DKFZp434F162; HiNF-P; MIZF; ZNF743

External IDs

OMIM: 607099 MGI: 2429620 HomoloGene: 9174 GeneCards: HINFP Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • protein binding • zinc ion binding • enzyme binding • histone binding • transcription regulatory region DNA binding • metal ion binding
Cellular component	• intracellular • nucleus • nucleoplasm • nucleolus • Cajal body
Biological process	• DNA damage checkpoint • G1/S transition of mitotic cell cycle • regulation of transcription involved in G1/S phase of mitotic cell cycle • in utero embryonic development • DNA repair • transcription, DNA-dependent • regulation of transcription, DNA-dependent • regulation of gene expression • positive regulation of gene expression • negative regulation of gene expression • establishment of protein localization • myoblast differentiation • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
118.99 – 119.01 Mb

Chr 9:
44.1 – 44.11 Mb

PubMed search

[1]

[2]

Histone H4 transcription factor is a protein that in humans is encoded by the HINFP gene.^[1]^[2]

MIZF interacts with methyl-CpG-binding protein-2 (MBD2; MIM 603547), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.[supplied by OMIM]^[2]

Interactions

MIZF has been shown to interact with Methyl-CpG-binding domain protein 2^[1] and DHX9.^[3]

References

^ ^a ^b Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (Nov 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J Biol Chem 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
^ ^a ^b "Entrez Gene: MIZF MBD2-interacting zinc finger". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25988.
^ Fujita, Hidetoshi; Fujii Ryouji, Aratani Satoko, Amano Tetsuya, Fukamizu Akiyoshi, Nakajima Toshihiro (Apr. 2003). "Antithetic effects of MBD2a on gene regulation". Mol. Cell. Biol. (United States) 23 (8): 2645–57. doi:10.1128/MCB.23.8.2645-2657.2003. ISSN 0270-7306. PMC 152551. PMID 12665568. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152551.

Medina R, van der Deen M, Miele-Chamberland A, et al. (2007). "The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.". Cancer Res. 67 (21): 10334–42. doi:10.1158/0008-5472.CAN-07-1560. PMID 17974976.
Mitra P, Xie R, Harper JW, et al. (2007). "HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription.". J. Cell. Biochem. 101 (1): 181–91. doi:10.1002/jcb.21157. PMID 17163457.
Fukushige S, Kondo E, Gu Z, et al. (2006). "RET finger protein enhances MBD2- and MBD4-dependent transcriptional repression.". Biochem. Biophys. Res. Commun. 351 (1): 85–92. doi:10.1016/j.bbrc.2006.10.005. PMID 17049487.
Pulukuri SM, Rao JS (2006). "CpG island promoter methylation and silencing of 14-3-3sigma gene expression in LNCaP and Tramp-C1 prostate cancer cell lines is associated with methyl-CpG-binding protein MBD2.". Oncogene 25 (33): 4559–72. doi:10.1038/sj.onc.1209462. PMC 1526774. PMID 16786000. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526774.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Miele A, Braastad CD, Holmes WF, et al. (2005). "HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition.". Mol. Cell. Biol. 25 (14): 6140–53. doi:10.1128/MCB.25.14.6140-6153.2005. PMC 1168814. PMID 15988025. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1168814.
Sekimata M, Homma Y (2005). "Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation.". Biochem. Biophys. Res. Commun. 325 (3): 653–9. doi:10.1016/j.bbrc.2004.10.090. PMID 15541338.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Sekimata M, Homma Y (2004). "Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF.". Nucleic Acids Res. 32 (2): 590–7. doi:10.1093/nar/gkh249. PMC 373363. PMID 14752047. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=373363.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitra P, Xie RL, Medina R, et al. (2003). "Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase.". Mol. Cell. Biol. 23 (22): 8110–23. doi:10.1128/MCB.23.22.8110-8123.2003. PMC 262391. PMID 14585971. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=262391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

MIZF

Interactions

References

Further reading