MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Identifiers

External IDs

OMIM: 602577 MGI: 1095404 HomoloGene: 1803 GeneCards: MFNG Gene

2.4.1.222

Gene Ontology
Molecular function	• transferase activity, transferring glycosyl groups • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
Cellular component	• Golgi membrane • extracellular space • Golgi apparatus • membrane • integral to membrane • integral to Golgi membrane
Biological process	• pattern specification process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
37.87 – 37.88 Mb

Chr 15:
78.59 – 78.6 Mb

PubMed search

[1]

[2]

Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene.^[1]^[2]^[3]

This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta1,3 N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.^[3]

References

^ Egan S, Herbrick JA, Tsui LC, Cohen B, Flock G, Beatty B, Scherer SW (Feb 1999). "Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12". Genomics 54 (3): 576–7. doi:10.1006/geno.1998.5559. PMID 9878264.
^ Johnston SH, Rauskolb C, Wilson R, Prabhakaran B, Irvine KD, Vogt TF (Jul 1997). "A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway". Development 124 (11): 2245–54. PMID 9187150.
^ ^a ^b "Entrez Gene: MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4242.

Cohen B, Bashirullah A, Dagnino L et al. (1997). "Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila". Nat. Genet. 16 (3): 283–8. doi:10.1038/ng0797-283. PMID 9207795.
Moran JL, Johnston SH, Rauskolb C et al. (1999). "Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes". Mamm. Genome 10 (6): 535–41. doi:10.1007/s003359901039. PMID 10341080.
Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Van Tine BA, Knops J, Shaw GM, May WA (2000). "Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH)". Cytogenet. Cell Genet. 87 (1–2): 132–3. doi:10.1159/000015379. PMID 10640833.
Moloney DJ, Panin VM, Johnston SH et al. (2000). "Fringe is a glycosyltransferase that modifies Notch". Nature 406 (6794): 369–75. doi:10.1038/35019000. PMID 10935626.
Shimizu K, Chiba S, Saito T et al. (2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
Thélu J, Rossio P, Favier B (2003). "Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing". BMC Dermatol. 2: 7. doi:10.1186/1471-5945-2-7. PMC 111189. PMID 11978185. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=111189.
Panin VM, Shao L, Lei L et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Shao L, Moloney DJ, Haltiwanger R (2003). "Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region". J. Biol. Chem. 278 (10): 7775–82. doi:10.1074/jbc.M212221200. PMID 12486116.
Veeraraghavalu K, Pett M, Kumar RV et al. (2004). "Papillomavirus-Mediated Neoplastic Progression Is Associated with Reciprocal Changes in Jagged1 and Manic Fringe Expression Linked to Notch Activation". J. Virol. 78 (16): 8687–700. doi:10.1128/JVI.78.16.8687-8700.2004. PMC 479091. PMID 15280477. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=479091.
Collins JE, Wright CL, Edwards CA et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

MFNG

References

Further reading