MED30

Mediator complex subunit 30

Identifiers

MED30; MED30S; MGC9890; THRAP6; TRAP25

External IDs

OMIM: 610237 MGI: 1917040 HomoloGene: 12329 GeneCards: MED30 Gene

Gene Ontology
Molecular function	• RNA polymerase II transcription cofactor activity • transcription cofactor activity • receptor activity • ligand-dependent nuclear receptor transcription coactivator activity • identical protein binding • vitamin D receptor binding • thyroid hormone receptor binding
Cellular component	• nucleus • nucleoplasm • mediator complex
Biological process	• transcription initiation from RNA polymerase II promoter • gene expression • steroid hormone receptor signaling pathway • androgen receptor signaling pathway • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
118.53 – 118.55 Mb

Chr 15:
52.54 – 52.56 Mb

PubMed search

[1]

[2]

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.^[1]

Interactions

MED30 has been shown to interact with MED22.^[2]

References

^ "Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90390.
^ Sato, Shigeo; Tomomori-Sato Chieri, Banks Charles A S, Sorokina Irina, Parmely Tari J, Kong Stephanie E, Jin Jingji, Cai Yong, Lane William S, Brower Christopher S, Conaway Ronald C, Conaway Joan Weliky (Apr. 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". J. Biol. Chem. (United States) 278 (17): 15123–7. doi:10.1074/jbc.C300054200. ISSN 0021-9258. PMID 12584197.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.". Mol. Cell 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.". J. Biol. Chem. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex.". J. Biol. Chem. 278 (50): 49671–4. doi:10.1074/jbc.C300444200. PMID 14576168.
Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3.". J. Biol. Chem. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Wang Q, Sharma D, Ren Y, Fondell JD (2003). "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.". J. Biol. Chem. 277 (45): 42852–8. doi:10.1074/jbc.M206061200. PMID 12218053.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=135748.
Baek HJ, Malik S, Qin J, Roeder RG (2002). "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s.". Mol. Cell. Biol. 22 (8): 2842–52. doi:10.1128/MCB.22.8.2842-2852.2002. PMC 133729. PMID 11909976. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133729.
Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein-protein interaction panel using mouse full-length cDNAs.". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311163.
Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation.". Nature 398 (6730): 828–32. doi:10.1038/19789. PMID 10235267.
Rachez C, Lemon BD, Suldan Z, et al. (1999). "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.". Nature 398 (6730): 824–8. doi:10.1038/19783. PMID 10235266.
Ito M, Yuan CX, Malik S, et al. (1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators.". Mol. Cell 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.

MED30

Interactions

References

Further reading