MED21

Mediator complex subunit 21
Identifiers
Symbols MED21; SRB7; SURB7
External IDs OMIM603800 MGI1347064 HomoloGene3148 GeneCards: MED21 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9412 108098
Ensembl ENSG00000152944 ENSMUSG00000030291
UniProt Q13503 n/a
RefSeq (mRNA) NM_004264 NM_025315.3
RefSeq (protein) NP_004255 NP_079591.1
Location (UCSC) Chr 12:
27.18 – 27.22 Mb
Chr 6:
146.59 – 146.6 Mb
PubMed search [1] [2]

Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the MED21 gene.[1][2]

Interactions

MED21 has been shown to interact with Cyclin-dependent kinase 8,[3][4][5][6] BRCA1,[7] GTF2H4,[7] MED6,[8] POLR2A[7][3][4] and GTF2F1.[7][4]

References

  1. ^ Chao DM, Gadbois EL, Murray PJ, Anderson SF, Sonu MS, Parvin JD, Young RA (Apr 1996). "A mammalian SRB protein associated with an RNA polymerase II holoenzyme". Nature 380 (6569): 82–5. doi:10.1038/380082a0. PMID 8598913. 
  2. ^ "Entrez Gene: SURB7 SRB7 suppressor of RNA polymerase B homolog (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9412. 
  3. ^ a b Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. 1998). "A human RNA polymerase II complex containing factors that modify chromatin structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109120. 
  4. ^ a b c Suñé, C; Hayashi T, Liu Y, Lane W S, Young R A, Garcia-Blanco M A (Oct. 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. (UNITED STATES) 17 (10): 6029–39. ISSN 0270-7306. PMC 232452. PMID 9315662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232452. 
  5. ^ Ito, M; Yuan C X, Malik S, Gu W, Fondell J D, Yamamura S, Fu Z Y, Zhang X, Qin J, Roeder R G (Mar. 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Mol. Cell (UNITED STATES) 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. ISSN 1097-2765. PMID 10198638. 
  6. ^ Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122401. 
  7. ^ a b c d Scully, R; Anderson S F, Chao D M, Wei W, Ye L, Young R A, Livingston D M, Parvin J D (May. 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (11): 5605–10. doi:10.1073/pnas.94.11.5605. ISSN 0027-8424. PMC 20825. PMID 9159119. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20825. 
  8. ^ Sun, X; Zhang Y, Cho H, Rickert P, Lees E, Lane W, Reinberg D (Aug. 1998). "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription". Mol. Cell (UNITED STATES) 2 (2): 213–22. doi:10.1016/S1097-2765(00)80131-8. ISSN 1097-2765. PMID 9734358. 

Further reading