MCRS1

Microspherule protein 1

Identifiers

MCRS1; ICP22BP; INO80Q; MCRS2; MSP58; P78

External IDs

OMIM: 609504 MGI: 1858420 HomoloGene: 4622 GeneCards: MCRS1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • Ino80 complex • MLL1 complex
Biological process	• DNA repair • DNA recombination • regulation of transcription, DNA-dependent • protein modification process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
49.95 – 49.96 Mb

Chr 15:
99.07 – 99.08 Mb

PubMed search

[1]

[2]

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.^[1]^[2]^[3]

Interactions

MCRS1 has been shown to interact with PHC2,^[4] Death associated protein 6,^[5] NOL1,^[2] PINX1^[6] and Telomerase reverse transcriptase.^[6]

References

^ Bruni R, Roizman B (Nov 1998). "Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells". J Virol 72 (11): 8525–31. PMC 110262. PMID 9765390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110262.
^ ^a ^b Ren Y, Busch RK, Perlaky L, Busch H (Jul 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120". Eur J Biochem 253 (3): 734–42. doi:10.1046/j.1432-1327.1998.2530734.x. PMID 9654073.
^ "Entrez Gene: MCRS1 microspherule protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10445.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Lin, Ding-Yen; Shih Hsiu-Ming (Jul. 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". J. Biol. Chem. (United States) 277 (28): 25446–56. doi:10.1074/jbc.M200633200. ISSN 0021-9258. PMID 11948183.
^ ^a ^b Song, Hai; Li Yiliang, Chen Guoyuan, Xing Zhen, Zhao Jing, Yokoyama Kazunari K, Li Tsaiping, Zhao Mujun (Apr. 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochem. Biophys. Res. Commun. (United States) 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. ISSN 0006-291X. PMID 15044100.

Lin DY, Shih HM (2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.". J. Biol. Chem. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Song H, Li Y, Chen G, et al. (2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.". Biochem. Biophys. Res. Commun. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Shimono K, Shimono Y, Shimokata K, et al. (2006). "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.". J. Biol. Chem. 280 (47): 39436–47. doi:10.1074/jbc.M507356200. PMID 16186106.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Hirohashi Y, Wang Q, Liu Q, et al. (2006). "p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.". Oncogene 25 (35): 4937–46. doi:10.1038/sj.onc.1209500. PMID 16547491.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
Davidovic L, Bechara E, Gravel M, et al. (2006). "The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons.". Hum. Mol. Genet. 15 (9): 1525–38. doi:10.1093/hmg/ddl074. PMID 16571602.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Du X, Wang Q, Hirohashi Y, Greene MI (2007). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.". Exp. Mol. Pathol. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Zhang J, Liu J, Li X, et al. (2007). "The physical and functional interaction of NDRG2 with MSP58 in cells.". Biochem. Biophys. Res. Commun. 352 (1): 6–11. doi:10.1016/j.bbrc.2006.10.141. PMID 17109818.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

MCRS1

Interactions

References

Further reading