MAPK7

Mitogen-activated protein kinase 7
Identifiers
Symbols	MAPK7; BMK1; ERK4; ERK5; PRKM7
External IDs	OMIM: 602521 MGI: 1346347 HomoloGene: 2060 GeneCards: MAPK7 Gene
EC number	2.7.11.24
Gene Ontology Molecular function • nucleotide binding • protein serine/threonine kinase activity • MAP kinase activity • protein binding • ATP binding Cellular component • nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol Biological process • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • apoptosis • cell cycle • signal transduction • Toll signaling pathway • peptidyl-serine phosphorylation • cell differentiation • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • innate immune response • regulation of angiogenesis • protein autophosphorylation • nerve growth factor receptor signaling pathway • stress-activated MAPK cascade • negative regulation of NFAT protein import into nucleus • BMK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5598	23939
Ensembl	ENSG00000166484	ENSMUSG00000001034
UniProt	Q13164	Q3U2N7
RefSeq (mRNA)	NM_002749.3	NM_011841.1
RefSeq (protein)	NP_002740.2	NP_035971.1
Location (UCSC)	Chr 17: 19.28 – 19.29 Mb	Chr 11: 61.3 – 61.31 Mb
PubMed search	[1]	[2]

Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene.^[1][2]

Contents 1 Function 2 Interactions 3 References 4 External Links 5 Further reading

Function

MAPK7 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor tyrosine kinases, and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.^[3]

MAPK7 is also critical for cardiovascular development ^[4] and is essential for endothelial cell function.^{[5] [6]}

Interactions

MAPK7 has been shown to interact with SGK,^[7] MEF2C,^[8] YWHAB,^[9] MEF2D,^[8] C-Raf,^[10] PTPRR,^[11] Gap junction protein, alpha 1^[12] and MAP2K5.^[2]

References

External Links

• MAP Kinase Resource .

Further reading