MAPK11

Mitogen-activated protein kinase 11

Rendering based on PDB 3GC8.
Identifiers
Symbols MAPK11; P38B; P38BETA2; PRKM11; SAPK2; SAPK2B; p38-2; p38Beta
External IDs OMIM602898 MGI1338024 HomoloGene55684 GeneCards: MAPK11 Gene
EC number 2.7.11.24
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5600 19094
Ensembl ENSG00000185386 ENSMUSG00000053137
UniProt Q15759 Q3TT60
RefSeq (mRNA) NM_002751 NM_011161.5
RefSeq (protein) NP_002742 NP_035291.4
Location (UCSC) Chr 22:
50.7 – 50.71 Mb
Chr 15:
88.97 – 88.98 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene.[1][2]

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.[2]

Contents

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Interactions

MAPK11 has been shown to interact with HDAC3[3] and Promyelocytic leukemia protein.[4]

See also

References

  1. ^ Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P (Aug 1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". EMBO J 16 (12): 3563–71. doi:10.1093/emboj/16.12.3563. PMC 1169981. PMID 9218798. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169981. 
  2. ^ a b "Entrez Gene: MAPK11 mitogen-activated protein kinase 11". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5600. 
  3. ^ Mahlknecht, Ulrich; Will Jutta, Varin Audrey, Hoelzer Dieter, Herbein Georges (Sep. 2004). "Histone deacetylase 3, a class I histone deacetylase, suppresses MAPK11-mediated activating transcription factor-2 activation and represses TNF gene expression". J. Immunol. (United States) 173 (6): 3979–90. ISSN 0022-1767. PMID 15356147. 
  4. ^ Shin, Jinwook; Park Boyoun, Cho Sunglim, Lee Sunray, Kim Youngkyun, Lee Seong-Ok, Cho Kwangmin, Lee Sungwook, Jin Bong-Suk, Ahn Jin-Hyun, Choi Eui-Ju, Ahn Kwangseog (Sep. 2004). "Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase". J. Biol. Chem. (United States) 279 (39): 40994–1003. doi:10.1074/jbc.M407369200. ISSN 0021-9258. PMID 15273249. 

External Links

Further reading