MAP3K7IP3
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1][2][3]
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
Interactions
MAP3K7IP3 has been shown to interact with MAP3K7IP2,[1] MAP3K7IP1[2] and MAP3K7.[1][2]
References
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Jin G, Klika A, Callahan M, et al. (2004). "Identification of a human NF-kappaB-activating protein, TAB3.". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2028–33. doi:10.1073/pnas.0307314101. PMC 357046. PMID 14766965. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=357046.
- Kanayama A, Seth RB, Sun L, et al. (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.". Mol. Cell 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Besse A, Lamothe B, Campos AD, et al. (2007). "TAK1-dependent signaling requires functional interaction with TAB2/TAB3.". J. Biol. Chem. 282 (6): 3918–28. doi:10.1074/jbc.M608867200. PMID 17158449.