MAP3K7IP2

TGF-beta activated kinase 1/MAP3K7 binding protein 2

PDB rendering based on 2dae.
Identifiers
Symbols TAB2; CHTD2; FLJ21885; KIAA0733; MAP3K7IP2
External IDs OMIM: 605101 MGI: 1915902 HomoloGene: 9019 GeneCards: TAB2 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 23118 68652
Ensembl ENSG00000055208 ENSMUSG00000015755
UniProt Q9NYJ8 Q99K90
RefSeq (mRNA) NM_015093 NM_138667.3
RefSeq (protein) NP_055908 NP_619608.1
Location (UCSC) Chr 6:
149.54 – 149.73 Mb		 Chr 10:
7.63 – 7.68 Mb
PubMed search [1] [2]

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.[1][2][2][3]

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.[3] Mutations in MAP3K7IP2 have been associated with human congenital heart defects.[4]

Interactions

MAP3K7IP2 has been shown to interact with NFKB1,[5] Nuclear receptor co-repressor 1,[5] TRAF2,[2][6] NUMBL,[7] TRAF6,[2][7][8][9][10][11] HDAC3,[5] MAP3K7IP1,[2][12][13] MAP3K7[2][9][13] and MAP3K7IP3.[8]

References

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
  2. ^ a b c d e f Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (Jul 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol Cell 5 (4): 649–58. doi:10.1016/S1097-2765(00)80244-0. PMID 10882101. 
  3. ^ a b "Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118. 
  4. ^ Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA (2010). "Haploinsufficiency of TAB2 causes congenital heart defects in humans.". Am J Hum Genet 86 (6): 839–49. doi:10.1016/j.ajhg.2010.04.011. PMC 3032066. PMID 20493459. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3032066. 
  5. ^ a b c Baek, Sung Hee; Ohgi Kenneth A, Rose David W, Koo Edward H, Glass Christopher K, Rosenfeld Michael G (Jul. 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell (United States) 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. ISSN 0092-8674. PMID 12150997. 
  6. ^ Li, Shitao; Wang Lingyan, Dorf Martin E (Jan. 2009). "PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination". Mol. Cell (United States) 33 (1): 30–42. doi:10.1016/j.molcel.2008.11.023. PMC 2643372. PMID 19150425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2643372. 
  7. ^ a b Ma, Qi; Zhou Li, Shi Huili, Huo Keke (Jun. 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. (England) 20 (6): 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187. 
  8. ^ a b Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. (England) 22 (23): 6277–88. doi:10.1093/emboj/cdg605. ISSN 0261-4189. PMC 291846. PMID 14633987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=291846. 
  9. ^ a b Takaesu, G; Ninomiya-Tsuji J, Kishida S, Li X, Stark G R, Matsumoto K (Apr. 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Mol. Cell. Biol. (United States) 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. ISSN 0270-7306. PMC 86880. PMID 11259596. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86880. 
  10. ^ Walsh, Matthew C; Kim Gregory K, Maurizio Paul L, Molnar Elizabeth E, Choi Yongwon (2008). Unutmaz, Derya. ed. "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL". PLoS ONE (United States) 3 (12): e4064. doi:10.1371/journal.pone.0004064. PMC 2603309. PMID 19112497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2603309. 
  11. ^ Windheim, Mark; Stafford Margaret, Peggie Mark, Cohen Philip (Mar. 2008). "Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase". Mol. Cell. Biol. (United States) 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2258775. 
  12. ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216. 
  13. ^ a b Cheung, Peter C F; Nebreda Angel R, Cohen Philip (Feb. 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. (England) 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223947. 

Further reading