MAP1LC3A

Microtubule-associated protein 1 light chain 3 alpha

Identifiers

MAP1LC3A; ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3

External IDs

OMIM: 601242 MGI: 1915661 HomoloGene: 12021 GeneCards: MAP1LC3A Gene

Gene Ontology
Molecular function	• protein binding • phospholipid binding • phosphatidylethanolamine binding
Cellular component	• autophagic vacuole membrane • cytoplasm • autophagic vacuole • cytosol • cytoskeleton • microtubule • endomembrane system • organelle membrane • cytoplasmic vesicle
Biological process	• autophagic vacuole assembly • autophagy
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
33.13 – 33.15 Mb

Chr 2:
155.1 – 155.1 Mb

PubMed search

[1]

[2]

Microtubule-associated proteins 1A/1B light chain 3A is a protein that in humans is encoded by the MAP1LC3A gene.^[1]^[2]^[3]

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.^[3]. MAPLC3A is the mammalian homologue of yeast ATG8, an important marker and effector of autophagy.

Interactions

MAP1LC3A has been shown to interact with Sequestosome 1.^[4]

References

^ Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088.
^ Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
^ ^a ^b "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84557.
^

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MAP1LC3A

Interactions

References

Further reading