MAP1B

Microtubule-associated protein 1B

Identifiers

MAP1B; DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP5

External IDs

OMIM: 157129 MGI: 1306778 HomoloGene: 38111 GeneCards: MAP1B Gene

Gene Ontology
Molecular function	• actin binding • structural molecule activity • protein binding • phospholipid binding • microtubule binding • protein complex binding
Cellular component	• soluble fraction • cytoplasm • cytosol • cytoskeleton • microtubule • microtubule associated complex • plasma membrane • postsynaptic density • axon • dendrite • growth cone • perikaryon • perinuclear region of cytoplasm
Biological process	• microtubule bundle formation • negative regulation of microtubule depolymerization • axonogenesis • synapse assembly • central nervous system development • response to mechanical stimulus • response to carbohydrate stimulus • embryo development • response to inorganic substance • peripheral nervous system axon regeneration • dendrite development • response to insecticide • developmental maturation • positive regulation of microtubule polymerization • response to nutrient levels • response to estradiol stimulus • negative regulation of intracellular transport • response to vitamin A • response to drug • response to peptide hormone stimulus • positive regulation of neuron differentiation • positive regulation of axon extension • mitochondrion transport along microtubule • neuron development • axon extension involved in development • response to axon injury • response to protein stimulus • induction of synaptic plasticity by chemical substance • establishment of monopolar cell polarity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
71.4 – 71.51 Mb

Chr 13:
100.19 – 100.29 Mb

PubMed search

[1]

[2]

Microtubule-associated protein 1B is a protein that in humans is encoded by the MAP1B gene.^[1]^[2]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.^[2]

Interactions

MAP1B has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[3] and RASSF1.^[4]

References

^ Lien LL, Boyce FM, Kleyn P, Brzustowicz LM, Menninger J, Ward DC, Gilliam TC, Kunkel LM (Oct 1991). "Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13". Proc Natl Acad Sci U S A 88 (17): 7873–6. doi:10.1073/pnas.88.17.7873. PMC 52406. PMID 1881920. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52406.
^ ^a ^b "Entrez Gene: MAP1B microtubule-associated protein 1B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131.
^ Opal, Puneet; Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y (Sep. 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. (United States) 278 (36): 34691–9. doi:10.1074/jbc.M302785200. ISSN 0021-9258. PMID 12807913.
^ Dallol, Ashraf; Agathanggelou Angelo, Fenton Sarah L, Ahmed-Choudhury Jalal, Hesson Luke, Vos Michele D, Clark Geoffrey J, Downward Julian, Maher Eamonn R, Latif Farida (Jun. 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. (United States) 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. ISSN 0008-5472. PMID 15205320.

Hammarback JA, Obar RA, Hughes SM, Vallee RB (1991). "MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain.". Neuron 7 (1): 129–39. doi:10.1016/0896-6273(91)90081-A. PMID 1712602.
Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS.". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J (1994). "Role of phosphorylated MAPlB in neuritogenesis.". Cell Biol. Int. 18 (5): 309–14. doi:10.1006/cbir.1994.1079. PMID 7519512.
Lien LL, Feener CA, Fischbach N, Kunkel LM (1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15.". Genomics 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
Ohyu J, Takashima S (1998). "Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions.". Brain Dev. 20 (1): 22–6. doi:10.1016/S0387-7604(97)00088-0. PMID 9533556.
Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC (1998). "Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium.". J. Cell. Sci. 111 ( Pt 10): 1351–61. PMID 9570753.
Tögel M, Wiche G, Propst F (1998). "Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain.". J. Cell Biol. 143 (3): 695–707. doi:10.1083/jcb.143.3.695. PMC 2148156. PMID 9813091. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2148156.
Hanley JG, Koulen P, Bedford F, et al. (1999). "The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses.". Nature 397 (6714): 66–9. doi:10.1038/16258. PMID 9892354.
Jensen PH, Islam K, Kenney J, et al. (2000). "Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments.". J. Biol. Chem. 275 (28): 21500–7. doi:10.1074/jbc.M000099200. PMID 10764738.
Tanner SL, Franzen R, Jaffe H, Quarles RH (2000). "Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein.". J. Neurochem. 75 (2): 553–62. doi:10.1046/j.1471-4159.2000.0750553.x. PMID 10899930.
Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition.". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287.
Billups D, Hanley JG, Orme M, et al. (2001). "GABAC receptor sensitivity is modulated by interaction with MAP1B.". J. Neurosci. 20 (23): 8643–50. PMID 11102469.
Franzen R, Tanner SL, Dashiell SM, et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein.". J. Cell Biol. 155 (6): 893–8. doi:10.1083/jcb.200108137. PMC 2150906. PMID 11733546. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150906.
Ding J, Liu JJ, Kowal AS, et al. (2002). "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin.". J. Cell Biol. 158 (3): 427–33. doi:10.1083/jcb.200202055. PMC 2173828. PMID 12147674. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173828.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA (2004). "Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region.". Biomol. Eng. 20 (3): 91–6. doi:10.1016/S1389-0344(03)00003-0. PMID 12684070.
Chang L, Jones Y, Ellisman MH, et al. (2003). "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.". Dev. Cell 4 (4): 521–33. doi:10.1016/S1534-5807(03)00094-7. PMID 12689591.
Opal P, Garcia JJ, Propst F, et al. (2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis.". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. PMID 12807913.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

MAP1B

Interactions

References

Further reading