MAP1A

Microtubule-associated protein 1A

Identifiers

MAP1A; FLJ77111; MAP1L; MTAP1A

External IDs

OMIM: 600178 HomoloGene: 1778 GeneCards: MAP1A Gene

Gene Ontology
Molecular function	• structural molecule activity • protein binding
Cellular component	• cytoplasm • cytoskeleton • microtubule • microtubule associated complex
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

NM_002373

n/a

RefSeq (protein)

NP_002364

n/a

Location (UCSC)

Chr 15:
43.8 – 43.83 Mb

Chr 2:
121.12 – 121.14 Mb

PubMed search

[1]

[2]

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene.^[1]^[2]^[3]

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.^[3]

Interactions

MAP1A has been shown to interact with DISC1.^[4]

References

^ Lien LL, Feener CA, Fischbach N, Kunkel LM (Jan 1995). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID 7806212.
^ Fukuyama R, Rapoport SI (Sep 1995). "Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15". J Neurosci Res 40 (6): 820–5. doi:10.1002/jnr.490400613. PMID 7629894.
^ ^a ^b "Entrez Gene: MAP1A microtubule-associated protein 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4130.
^ Morris, Jill A; Kandpal Geeta, Ma Lei, Austin Christopher P (Jul. 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. (England) 12 (13): 1591–608. doi:10.1093/hmg/ddg162. ISSN 0964-6906. PMID 12812986.

Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease.". Folia Biol. (Praha) 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639.
Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases". J. Gen. Virol. 71 ( Pt 9) (9): 1985–91. doi:10.1099/0022-1317-71-9-1985. PMID 2212989.
Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. PMID 2470876.
Bloom GS, Luca FC, Vallee RB (1984). "Widespread cellular distribution of MAP-1A (microtubule-associated protein 1A) in the mitotic spindle and on interphase microtubules". J. Cell Biol. 98 (1): 331–40. doi:10.1083/jcb.98.1.331. PMC 2113021. PMID 6142895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2113021.
Pedrotti B, Colombo R, Islam K (1995). "Microtubule associated protein MAP1A is an actin-binding and crosslinking protein". Cell Motil. Cytoskeleton 29 (2): 110–6. doi:10.1002/cm.970290203. PMID 7820861.
Fujii T, Watanabe M, Ogoma Y, et al. (1994). "Microtubule-associated proteins, MAP 1A and MAP 1B, interact with F-actin in vitro". J. Biochem. 114 (6): 827–9. PMID 7908020.
Mann SS, Hammarback JA (1994). "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B". J. Biol. Chem. 269 (15): 11492–7. PMID 7908909.
Fink JK, Jones SM, Esposito C, Wilkowski J (1996). "Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression". Genomics 35 (3): 577–85. doi:10.1006/geno.1996.0400. PMID 8812494.
Vaillant AR, Müller R, Langkopf A, Brown DL (1998). "Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics". J. Biol. Chem. 273 (22): 13973–81. doi:10.1074/jbc.273.22.13973. PMID 9593747.
Brenman JE, Topinka JR, Cooper EC, et al. (1998). "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A". J. Neurosci. 18 (21): 8805–13. PMID 9786987.
Hirst J, Lui WW, Bright NA, et al. (2000). "A Family of Proteins with γ-Adaptin and Vhs Domains That Facilitate Trafficking between the Trans-Golgi Network and the Vacuole/Lysosome". J. Cell Biol. 149 (1): 67–80. doi:10.1083/jcb.149.1.67. PMC 2175106. PMID 10747088. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175106.
Mei X, Sweatt AJ, Hammarback JA (2000). "Regulation of microtubule-associated protein 1B (MAP1B) subunit composition". J. Neurosci. Res. 62 (1): 56–64. doi:10.1002/1097-4547(20001001)62:1<56::AID-JNR6>3.0.CO;2-#. PMID 11002287.
Ulfig N, Feldhaus C, Setzer M, Bohl J (2001). "Expression of MAP1a and MAP1b in the ganglionic eminence and the internal capsule of the human fetal brain". Neurosci. Res. 38 (4): 397–405. doi:10.1016/S0168-0102(00)00189-9. PMID 11164566.
Bonnet C, Boucher D, Lazereg S, et al. (2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". J. Biol. Chem. 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
Orzech E, Livshits L, Leyt J, et al. (2001). "Interactions between adaptor protein-1 of the clathrin coat and microtubules via type 1a microtubule-associated proteins". J. Biol. Chem. 276 (33): 31340–8. doi:10.1074/jbc.M101054200. PMID 11418592.
Noiges R, Eichinger R, Kutschera W, et al. (2002). "Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties". J. Neurosci. 22 (6): 2106–14. PMID 11896150.
Ikeda A, Zheng QY, Zuberi AR, et al. (2002). "Microtubule-associated protein 1A is a modifier of tubby hearing (moth1)". Nat. Genet. 30 (4): 401–5. doi:10.1038/ng838. PMC 2862212. PMID 11925566. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2862212.

MAP1A

Interactions

References

Further reading