MAGED1

Melanoma antigen family D, 1

Identifiers

MAGED1; DLXIN-1; NRAGE

External IDs

OMIM: 300224 MGI: 1930187 HomoloGene: 5077 GeneCards: MAGED1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • plasma membrane • protein complex
Biological process	• regulation of transcription, DNA-dependent • apoptosis • apoptosis • induction of apoptosis by extracellular signals • regulation of apoptosis • nerve growth factor receptor signaling pathway • negative regulation of epithelial cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
51.55 – 51.65 Mb

Chr X:
91.78 – 91.79 Mb

PubMed search

[1]

[2]

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.^[1]^[2]

This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene.^[2]

Interactions

MAGED1 has been shown to interact with UNC5A,^[3] PJA1^[4] and XIAP.^[5]

References

^ Pold M, Zhou J, Chen GL, Hall JM, Vescio RA, Berenson JR (Sep 1999). "Identification of a new, unorthodox member of the MAGE gene family". Genomics 59 (2): 161–7. doi:10.1006/geno.1999.5870. PMID 10409427.
^ ^a ^b "Entrez Gene: MAGED1 melanoma antigen family D, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9500.
^ Williams, Megan E; Strickland Phyllis, Watanabe Ken, Hinck Lindsay (May. 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. (United States) 278 (19): 17483–90. doi:10.1074/jbc.M300415200. ISSN 0021-9258. PMID 12598531.
^ Sasaki, Aya; Masuda Yoshiko, Iwai Kazuhiro, Ikeda Kyoji, Watanabe Ken (Jun. 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. (United States) 277 (25): 22541–6. doi:10.1074/jbc.M109728200. ISSN 0021-9258. PMID 11959851.
^ Jordan, B W; Dinev D, LeMellay V, Troppmair J, Gotz R, Wixler L, Sendtner M, Ludwig S, Rapp U R (Oct. 2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death". J. Biol. Chem. (United States) 276 (43): 39985–9. doi:10.1074/jbc.C100171200. ISSN 0021-9258. PMID 11546791.

Salehi AH, Roux PP, Kubu CJ, et al. (2000). "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.". Neuron 27 (2): 279–88. doi:10.1016/S0896-6273(00)00036-2. PMID 10985348.
Masuda Y, Sasaki A, Shibuya H, et al. (2001). "Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function.". J. Biol. Chem. 276 (7): 5331–8. doi:10.1074/jbc.M008590200. PMID 11084035.
Kubu CJ, Goldhawk DG, Barker PA, Verdi JM (2001). "Identification of the translational initiation codon in human MAGED1.". Genomics 70 (1): 150–2. doi:10.1006/geno.2000.6356. PMID 11087672.
Zhang CG, Xing GC, Wei HD, et al. (2001). "[A new melanoma antigen-encoding gene subfamily in human chromosome X]". Yi Chuan Xue Bao 28 (3): 197–203. PMID 11280991.
Stone B, Schummer M, Paley PJ, et al. (2001). "MAGE-F1, a novel ubiquitously expressed member of the MAGE superfamily.". Gene 267 (2): 173–82. doi:10.1016/S0378-1119(01)00406-1. PMID 11313144.
Jordan BW, Dinev D, LeMellay V, et al. (2001). "Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death.". J. Biol. Chem. 276 (43): 39985–9. doi:10.1074/jbc.C100171200. PMID 11546791.
Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
Xu YC, Wu RF, Gu Y, et al. (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.". J. Biol. Chem. 277 (31): 28051–7. doi:10.1074/jbc.M202665200. PMID 12023963.
Kendall SE, Goldhawk DE, Kubu C, et al. (2003). "Expression analysis of a novel p75(NTR) signaling protein, which regulates cell cycle progression and apoptosis.". Mech. Dev. 117 (1–2): 187–200. doi:10.1016/S0925-4773(02)00204-6. PMID 12204258.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Williams ME, Strickland P, Watanabe K, Hinck L (2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". J. Biol. Chem. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
Matsuda T, Suzuki H, Oishi I, et al. (2003). "The receptor tyrosine kinase Ror2 associates with the melanoma-associated antigen (MAGE) family protein Dlxin-1 and regulates its intracellular distribution". J. Biol. Chem. 278 (31): 29057–64. doi:10.1074/jbc.M302199200. PMID 12754255.
Wen CJ, Xue B, Qin WX, et al. (2004). "hNRAGE, a human neurotrophin receptor interacting MAGE homologue, regulates p53 transcriptional activity and inhibits cell proliferation". FEBS Lett. 564 (1–2): 171–6. doi:10.1016/S0014-5793(04)00353-9. PMID 15094062.
Bertrand M, Huijbers I, Chomez P, De Backer O (2005). "Comparative expression analysis of the MAGED genes during embryogenesis and brain development". Dev. Dyn. 230 (2): 325–34. doi:10.1002/dvdy.20026. PMID 15162511.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
Tian XX, Rai D, Li J, et al. (2005). "BRCA2 suppresses cell proliferation via stabilizing MAGE-D1". Cancer Res. 65 (11): 4747–53. doi:10.1158/0008-5472.CAN-05-0018. PMID 15930293.
Xue B, Wen C, Shi Y, et al. (2005). "Human NRAGE disrupts E-cadherin/beta-catenin regulated homotypic cell-cell adhesion". Biochem. Biophys. Res. Commun. 336 (1): 247–51. doi:10.1016/j.bbrc.2005.08.069. PMID 16125672.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

MAGED1

Interactions

References

Further reading