MAFK

V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
Identifiers
Symbols MAFK; FLJ32205; MGC71717; NFE2U; P18
External IDs OMIM: 600197 MGI: 99951 HomoloGene: 1770 GeneCards: MAFK Gene
Orthologs
Species Human Mouse
Entrez 7975 17135
Ensembl ENSG00000198517 ENSMUSG00000018143
UniProt O60675 Q3U568
RefSeq (mRNA) NM_002360 NM_010757.2
RefSeq (protein) NP_002351 NP_034887.1
Location (UCSC) Chr 7:
1.57 – 1.58 Mb		 Chr 5:
140.27 – 140.28 Mb
PubMed search [1] [2]

Transcription factor MafK is a protein that in humans is encoded by the MAFK gene.[1][2]

The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 177000). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM][2]

References

  1. ^ Iwata T, Kogame K, Toki T, Yokoyama M, Yamamoto M, Ito E (Nov 1998). "Structure and chromosome mapping of the human small maf-genes MAFG and MAFK". Cytogenet Cell Genet 82 (1–2): 88–90. doi:10.1159/000015071. PMID 9763667. 
  2. ^ a b "Entrez Gene: MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7975. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.