MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

PDB rendering based on 1duj.
Identifiers
Symbols MAD2L1; HSMAD2; MAD2
External IDs OMIM: 601467 MGI: 1860374 HomoloGene: 1768 GeneCards: MAD2L1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4085 56150
Ensembl ENSG00000164109 ENSMUSG00000029910
UniProt Q13257 Q3TV93
RefSeq (mRNA) NM_002358 NM_019499.4
RefSeq (protein) NP_002349 NP_062372.2
Location (UCSC) Chr 4:
120.98 – 120.99 Mb		 Chr 6:
66.47 – 66.47 Mb
PubMed search [1] [2]

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[1][2][3]

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14.[3]

Interactions

MAD2L1 has been shown to interact with MAD2L2,[4] CDC20,[5][6][7][8][9][10][11][12][13][14][15][16] BUB1B,[17] Estrogen receptor beta,[18] ADAM17,[19][20] UBD,[21] CDC27[11][12] and Mad1.[22][8][4]

References

  1. ^ Li Y, Benezra R (Oct 1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science 274 (5285): 246–8. doi:10.1126/science.274.5285.246. PMID 8824189. 
  2. ^ Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (Nov 1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet Cell Genet 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911. 
  3. ^ a b "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4085. 
  4. ^ a b Murakumo, Y; Roth T, Ishii H, Rasio D, Numata S, Croce C M, Fishel R (Feb. 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. (UNITED STATES) 275 (6): 4391–7. doi:10.1074/jbc.275.6.4391. ISSN 0021-9258. PMID 10660610. 
  5. ^ Zhang, Y; Lees E (Aug. 2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. (United States) 21 (15): 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. ISSN 0270-7306. PMC 87243. PMID 11438673. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=87243. 
  6. ^ Sihn, Choong-Ryoul; Suh Eun-Jung, Lee Kee-Ho, Kim Tae-Yoon, Kim Sang Hoon (Nov. 2003). "p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells". Cancer Lett. (Ireland) 201 (2): 203–10. doi:10.1016/S0304-3835(03)00465-8. ISSN 0304-3835. PMID 14607335. 
  7. ^ Luo, X; Fang G, Coldiron M, Lin Y, Yu H, Kirschner M W, Wagner G (Mar. 2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. (UNITED STATES) 7 (3): 224–9. doi:10.1038/73338. ISSN 1072-8368. PMID 10700282. 
  8. ^ a b Sironi, L; Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A (Nov. 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. (England) 20 (22): 6371–82. doi:10.1093/emboj/20.22.6371. ISSN 0261-4189. PMC 125308. PMID 11707408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125308. 
  9. ^ D'Angiolella, Vincenzo; Mari Cecilia, Nocera Donatella, Rametti Linda, Grieco Domenico (Oct. 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes Dev. (United States) 17 (20): 2520–5. doi:10.1101/gad.267603. ISSN 0890-9369. PMC 218146. PMID 14561775. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=218146. 
  10. ^ Kallio, Marko J; Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J (Sep. 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. (United States) 158 (5): 841–7. doi:10.1083/jcb.200201135. ISSN 0021-9525. PMC 2173153. PMID 12196507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173153. 
  11. ^ a b Wassmann, K; Benezra R (Sep. 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (19): 11193–8. doi:10.1073/pnas.95.19.11193. ISSN 0027-8424. PMC 21618. PMID 9736712. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21618. 
  12. ^ a b Kallio, M; Weinstein J, Daum J R, Burke D J, Gorbsky G J (Jun. 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. (UNITED STATES) 141 (6): 1393–406. doi:10.1083/jcb.141.6.1393. ISSN 0021-9525. PMC 2132789. PMID 9628895. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132789. 
  13. ^ Fang, G; Yu H, Kirschner M W (Jun. 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. (UNITED STATES) 12 (12): 1871–83. doi:10.1101/gad.12.12.1871. ISSN 0890-9369. PMC 316912. PMID 9637688. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316912. 
  14. ^ Skoufias, D A; Andreassen P R, Lacroix F B, Wilson L, Margolis R L (Apr. 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (8): 4492–7. doi:10.1073/pnas.081076898. ISSN 0027-8424. PMC 31862. PMID 11274370. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31862. 
  15. ^ Nilsson, Jakob; Yekezare Mona, Minshull Jeremy, Pines Jonathon (Dec. 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. (England) 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2635557. 
  16. ^ Privette, Lisa M; Weier Jingly Fung, Nguyen Ha Nam, Yu Xiaochun, Petty Elizabeth M (Jul. 2008). "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint". Neoplasia (Canada) 10 (7): 643–52. PMC 2435002. PMID 18592005. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2435002. 
  17. ^ Sudakin, V; Chan G K, Yen T J (Sep. 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. (United States) 154 (5): 925–36. doi:10.1083/jcb.200102093. ISSN 0021-9525. PMC 2196190. PMID 11535616. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196190. 
  18. ^ Poelzl, G; Kasai Y, Mochizuki N, Shaul P W, Brown M, Mendelsohn M E (Mar. 2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (6): 2836–9. doi:10.1073/pnas.050580997. ISSN 0027-8424. PMC 16016. PMID 10706629. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16016. 
  19. ^ Nelson, K K; Schlöndorff J, Blobel C P (Nov. 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. (ENGLAND) 343 Pt 3: 673–80. ISSN 0264-6021. PMC 1220601. PMID 10527948. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220601. 
  20. ^ Poghosyan, Zaruhi; Robbins Stephen M, Houslay Miles D, Webster Ailsa, Murphy Gillian, Edwards Dylan R (Feb. 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. (United States) 277 (7): 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929. 
  21. ^ Liu, Y C; Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M (Apr. 1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (8): 4313–8. doi:10.1073/pnas.96.8.4313. ISSN 0027-8424. PMC 16329. PMID 10200259. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16329. 
  22. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading