This list of Florida Southern College alumni includes graduates, non-graduate former students and current students of Florida Southern College.
| Alumni | Notability |
|---|---|
| Robert M. Blackburn | Bishop of the United Methodist Church (B.A., 1941) |
| Megan Brown | Pitcher for the Rockford Thunder of the NPF |
| Amanda Curry Brown[1] | Economist at United States Environmental Protection Agency |
| Eric Eisnaugle | Current member of the Florida House of Representatives |
| Robert Eugene Fannin | Bishop of the United Methodist Church (B.S. in Business Administration) |
| Robert L. Goulet | CEO of Entertainment Sports Partners |
| Lee Janzen | Professional golfer on the PGA Tour |
| Matt Joyce | Major League rightfielder - Tampa Bay Rays |
| R. Fred Lewis | Former Chief Justice for the Florida Supreme Court |
| Rocco Mediate | Professional golfer on the PGA Tour |
| Robert L. McLendon, Jr. | Former President of St. Johns River Community College |
| Lance Niekro | Former Major League first baseman - four seasons in the majors |
| Brett Tomko | former Major League Pitcher - 11 seasons in the majors |
| Baxter Troutman | Current member of the Florida House of Representatives |
| Stephen R. Wise | Current member of the Florida Senate |
| Jon Gaylord | Prestigious Religion Alumnus |