Liprin-alpha-1
Liprin-alpha-1 is a protein that in humans is encoded by the PPFIA1 gene.[1][2][3]
The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]
Interactions
Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 has been shown to interact with PTPRF,[1][2][4] GRIP2,[5][6] PTPRD,[4] PPP2R5D,[7] PPFIBP1,[2] PTPRS,[2][4] ERC2[5] and GIT1.[5][6]
References
- ^ a b Serra-Pages C, Kedersha NL, Fazikas L, Medley Q, Debant A, Streuli M (Aug 1995). "The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions". EMBO J 14 (12): 2827–2838. PMC 398401. PMID 7796809. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=398401.
- ^ a b c d Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem 273 (25): 15611–15620. doi:10.1074/jbc.273.25.15611. PMID 9624153.
- ^ a b "Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8500.
- ^ a b c Pulido, R; Serra-Pagès C, Tang M, Streuli M (Dec. 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (25): 11686–11690. doi:10.1073/pnas.92.25.11686. ISSN 0027-8424. PMC 40467. PMID 8524829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40467.
- ^ a b c Ko, Jaewon; Na Moonseok, Kim Seho, Lee Jae-Ran, Kim Eunjoon (Oct. 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. (United States) 278 (43): 42377–42385. doi:10.1074/jbc.M307561200. ISSN 0021-9258. PMID 12923177.
- ^ a b Ko, Jaewon; Kim Seho, Valtschanoff Juli G, Shin Hyewon, Lee Jae-Ran, Sheng Morgan, Premont Richard T, Weinberg Richard J, Kim Eunjoon (Mar. 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. (United States) 23 (5): 1667–1677. PMID 12629171.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Pulido R, Serra-Pagès C, Tang M, Streuli M (1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11686–11690. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=40467.
- Wyszynski M, Kim E, Dunah AW, et al. (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.". Neuron 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. PMID 11931740.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ko J, Kim S, Valtschanoff JG, et al. (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.". J. Neurosci. 23 (5): 1667–1677. PMID 12629171.
- Ko J, Na M, Kim S, et al. (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins.". J. Biol. Chem. 278 (43): 42377–42385. doi:10.1074/jbc.M307561200. PMID 12923177.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
- Serra-Pagès C, Streuli M, Medley QG (2006). "Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation.". Biochemistry 44 (48): 15715–15724. doi:10.1021/bi051434f. PMC 2529169. PMID 16313174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2529169.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Hoogenraad CC, Feliu-Mojer MI, Spangler SA, et al. (2007). "Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.". Dev. Cell 12 (4): 587–602. doi:10.1016/j.devcel.2007.02.006. PMID 17419996.