Inbreeding

Inbreeding is the reproduction from the mating of two genetically related parents. Inbreeding results in increased homozygosity, which can increase the chances of offspring being affected by recessive or deleterious traits. This generally leads to a decreased fitness of a population, which is called inbreeding depression.

Livestock breeders often practice controlled breeding to eliminate undesirable characteristics within a population, which is also coupled with culling of what is considered unfit offspring, especially when trying to establish a new and desirable trait in the stock.

In plant breeding, inbred lines are used as stocks for the creation of hybrid lines to make use of the effects of heterosis. Inbreeding in plants also occurs naturally in the form of self-pollination.

Contents

Results

Inbreeding may result in a far higher phenotypic expression of deleterious recessive genes within a population than would normally be expected.[1] As a result, first-generation inbred individuals are more likely to show physical and health defects, including:

Natural selection works to remove individuals with the above types of traits from the gene pool. Therefore, many more individuals in the first generation of inbreeding will never live to reproduce. Over time, with isolation such as a population bottleneck caused by purposeful (assortative) breeding or natural environmental stresses, the deleterious inherited traits are culled.

Island species are often very inbred, as their isolation from the larger group on a mainland allows for natural selection to work upon their population. This type of isolation may result in the formation of race or even speciation, as the inbreeding first removes many deleterious genes, and allows expression of genes that allow a population to adapt to an ecosystem. As the adaptation becomes more pronounced the new species or race radiates from its entrance into the new space, or dies out if it cannot adapt and, most importantly, reproduce.[2]

The reduced genetic diversity that results from inbreeding may mean a species may not be able to adapt to changes in environmental conditions. Each individual will have similar immune systems, as immune systems are genetically based. Where a species becomes endangered, the population may fall below a minimum whereby the forced interbreeding between the remaining animals will result in extinction.

Natural breedings include inbreeding by necessity, and most animals only migrate when necessary. In many cases, the closest available mate is a mother, sister, grandmother, father, grandfather... In all cases the environment presents stresses to remove those individuals who cannot survive because of illness from the population.

There was an assumption that wild populations do not inbreed; this is not what is observed in some cases in the wild. However, in species such as horses, animals in wild or feral conditions often drive off the young of both genders, thought to be a mechanism by which the species instinctively avoids some of the genetic consequences of inbreeding.[3] In general, many mammal species including humanity's closest primate relatives avoid close inbreeding possibly due to the deleterious effects.[4]

Examples

The cheetah was once reduced by disease, habitat restriction, overhunting of prey, and competition from other predators to a very small number of individuals.[5][6] All cheetahs now come from this very small gene pool. Should a virus appear that none of the cheetahs have resistance to, extinction is always a possibility. Currently, the threatening virus is feline infectious peritonitis, which has a disease rate in domestic cats from 1%–5%; in the cheetah population it is ranging between 50% to 60%. The cheetah is also known, in spite of its small gene pool, for few genetic illnesses.

In the South American sea lion, there was concern that recent population crashes would reduce genetic diversity. Historical analysis indicated that a population expansion from just two matrilineal lines were responsible for most individuals within the population. Even so, the diversity within the lines allowed for great variation in the gene pool that may help to protect the South American sea lion from extinction.[7]

In lions, prides are often followed by related males in bachelor groups. When the dominant male is killed or driven off by one of these bachelors, a father may be replaced with his son. There is no mechanism for preventing inbreeding or to ensure outcrossing. In the prides, most lionesses are related to one another. If there is more than one dominant male, the group of alpha males are usually related. Two lines are then being "line bred". Also, in some populations such as the Crater lions, it is known that a population bottleneck has occurred. Researchers found far greater genetic heterozygosity than expected.[8] In fact, predators are known for low genetic variance, along with most of the top portion of the tropic levels of an ecosystem.[9] Additionally, the alpha males of two neighboring prides can potentially be from the same litter; one brother may come to acquire leadership over another's pride, and subsequently mate with his 'nieces' or cousins. However, killing another male's cubs, upon the takeover, allows for the new selected gene complement of the incoming alpha male to prevail over the previous male. There are genetic assays being scheduled for lions to determine their genetic diversity. The preliminary studies show results inconsistent with the outcrossing paradigm based on individual environments of the studied groups.[8]

Calculation

The inbreeding is computed as a percentage of chances for two alleles to be identical by descent. This percentage is called "inbreeding coefficient". There are several methods to compute this percentage, the two main ways are the path method[10] and the tabular method.[11]

Typical inbreeding coefficient percentages are as follows, assuming no previous inbreeding between any parents:

An inbreeding calculation may be used to determine the general genetic distance among relatives by multiplying by two, because any progeny would have a 1 in 2 risk of actually inheriting the identical alleles from both parents.

For instance, the parent/child or sibling/sibling relationships have 50% identical genetics.

NOTE: For siblings, the degree of genetic relationship is not an automatic 50% as it is with parents and their children, but a range from 100% at one extreme, as in the case of identical twins (who obviously cannot mate as they are the same sex), to an exceedingly unlikely 0%. In other words, siblings share an average of 50% of their genes, but unlike the 50% ratio between parents and children, the actual ratio between siblings in any given case can vary.

Domestic animals

Breeding in domestic animals is assortative breeding primarily (see selective breeding). Without the sorting of individuals by trait, a breed could not be established, nor could poor genetic material be removed. Homozygosity is the case where similar or identical alleles combine to express a trait that is not otherwise expressed (recessiveness). Inbreeding, through homozygosity, exposes recessive alleles. Inbreeding is used to reveal deleterious recessive alleles, which can then be eliminated through assortative breeding or through culling.

Inbreeding is used by breeders of domestic animals to fix desirable genetic traits within a population or to attempt to remove deleterious traits by allowing them to manifest phenotypically from the genotypes. Inbreeding is defined as the use of close relations for breeding such as mother to son, father to daughter, brother to sister.

Breeders must cull unfit breeding suppressed individuals and/or individuals who demonstrate either homozygosity or heterozygosity for genetic based diseases.[13] The issue of casual breeders who inbreed irresponsibly is discussed in the following quotation on cattle:

Meanwhile, milk production per cow per lactation increased from 17,444 lbs to 25,013 lbs from 1978 to 1998 for the Holstein breed. Mean breeding values for milk of Holstein cows increased by 4,829 lbs during this period.[14] High producing cows are increasingly difficult to breed and are subject to higher health costs than cows of lower genetic merit for production (Cassell, 2001). Intensive selection for higher yield has increased relationships among animals within breed and increased the rate of casual inbreeding. Many of the traits that affect profitability in crosses of modern dairy breeds have not been studied in designed experiments. Indeed, all crossbreeding research involving North American breeds and strains is very dated (McAllister, 2001) if it exists at all.[15]

Linebreeding is a form of inbreeding. There is no clear distinction between the two terms, but linebreeding may encompass crosses between individuals and their descendants or two cousins.[12][16] This method can be used to increase a particular animal's contribution to the population.[12] While linebreeding is less likely to cause problems in the first generation than does inbreeding, over time, linebreeding can reduce the genetic diversity of a population and cause problems related to a too-small genepool that may include an increased prevalence of genetic disorders and inbreeding depression.

Outcrossing is where two unrelated individuals have been crossed to produce progeny. In outcrossing, unless there is verifiable genetic information, one may find that all individuals are distantly related to an ancient progenitor. If the trait carries throughout a population, all individuals can have this trait. This is called the founder's effect. In the well established breeds, that are commonly bred,a large gene pool is present. For example, in 2004, over 18,000 Persian cats were registered.[17] A possibility exists for a complete outcross, if no barriers exist between the individuals to breed. However it is not always the case, and a form of distant linebreeding occurs. Again it is up to the assortative breeder to know what sort of traits both positive and negative exist within the diversity of one breeding. This diversity of genetic expression, within even close relatives, increases the variability and diversity of viable stock.[18]

The two dog sites above also point out that in the registered dog population, the onset of large numbers of casual breeders has corresponded with an increase in the number of genetic illnesses of dogs by not understanding how, why and which traits are inherited. The dog sites indicate that the largest percentage of dog breeders in the US are casual breeders. Therefore the investment in a papered animal,with an expected short term profit, motivates some to ignore the practice of culling. Casual breeders in companion animals often ignore breeding restrictions within their contracts with source companion animal breeders. The casual breeders breed the very culls that a genetics based breeder has released as a pet. The casual breeder was also cited in the quotes above on cattle raising.

Laboratory animals

Systematic inbreeding and maintenance of inbred strains of laboratory mice and rats is of great importance for biomedical research. The inbreeding guarantees a consistent and uniform animal model for experimental purposes and enables genetic studies in congenic and knock-out animals. The use of inbred strains is also important for genetic studies in animal models, for example to distinguish genetic from environmental effects.

Humans

Genetic disorders

In a review of 48 studies on the children had between cousins, most of the babies born to cousins were healthy contrary to the popular perception, with birth defects being 4% of births for consanguineous couples as opposed to 2% for the general population.[19] Inbreeding over many generations does increase risks however. The offspring of consanguineous relationships are at greater risk of certain genetic disorders. Autosomal recessive disorders occur in individuals who are homozygous for a particular recessive gene mutation. This means that they carry two copies of the same gene (allele). Except in certain rare circumstances (new mutations or uniparental disomy) both parents of an individual with such a disorder will be carriers of the gene. Such carriers are not affected and will not display any signs that they are carriers, and so may be unaware that they carry the mutated gene. As relatives share a proportion of their genes, it is much more likely that related parents will be carriers of the same autosomal recessive gene, and therefore their children are at a higher risk of an autosomal recessive disorder. The extent to which the risk increases depends on the degree of genetic relationship between the parents; so the risk is greater in mating relationships where the parents are close relatives, but for relationships between more distant relatives, such as second cousins, the risk is lower (although still greater than the general population).[20] A 1994 study found the progeny of first cousins, in Pakistan, indicate morbidity levels to be some 1% to 4% higher than in the offspring of unrelated couples. They went on to report, however, that this number was significantly inflated by sociodemographic variables.[21]

Prohibitions to inbreeding

The taboo of incest has been discussed by many social scientists. As anthropologists attest, this taboo exists in most cultures. As inbreeding within the first generation often produces expression of recessive traits, the prohibition has been discussed as a possible functional response to the requirement of culling those born deformed, or with undesirable traits. Some biologists like Charles Davenport advocated traditional forms of assortative breeding, i.e., eugenics, to form better "human stock".

Some Hindus follow the Gotra system, which prescribes prohibition of marriages among relatives based on a name attached to paternal relatives, to prevent inbreeding. Direct inbreeding is also prohibited in Islam, as described in the Quran (chapter 4, verse 23).

Royalty and nobility

The family relationships of royalty are usually very well known, leading observers to view royalty as highly inbred, but they are often comparable to many ethnic groups where the relationships are not publicized as well. Royal intermarriage was often practised to protect property, wealth, and position.

Isolated groups

Among genetic populations that are isolated, opportunities for exogamy are reduced. Isolation may be geographical, leading to inbreeding among people in remote mountain valleys. Or isolation may be social, induced by the lack of appropriate partners, such as Protestant princesses for Protestant royal heirs, in which case inbreeding is desired. Since the late Middle Ages, it is the urban middle class that has had the widest opportunity for outbreeding and the least desire to inbreed.

Some inbreeding may enhance fertility rate

A recent study in Iceland by the deCODE genetics company, published by the journal Science, found that third cousins produced more children and grandchildren, suggesting that "in spite of the fact that bringing together two alleles of a recessive trait may be bad, there is clearly some biological wisdom in the union of relatively closely related people.".[29] For hundreds of years, inbreeding was historically unavoidable in Iceland due to its then tiny and isolated population.[30]

See also

References

  1. ^ Griffiths, Anthony J. F.; Jeffrey H. Miller, David T. Suzuki, Richard C. Lewontin, William M. Gelbart (1999). An introduction to genetic analysis. New York: W. H. Freeman. pp. 726–727. ISBN 0-7167-3771-X. 
  2. ^ CHARLES F. LECK. "ESTABLISHMENT OF NEW POPULATION CENTERS WITH CHANGES IN MIGRATION PATTERNS." Journal of Field Ornithology, Spring 1980 Vol. 51, No. 2
  3. ^ "ADVS 3910 Wild Horses Behavior", College of Agriculture, Utah State University.
  4. ^ Inbreeding, incest, and the incest taboo: the state of knowledge at the turn, Arthur P. Wolf and William H. Durham (Editors), Stanford University Press, 2005, page 6
  5. ^ "Cheetahs". Archived from the original on January 25, 2008. http://web.archive.org/web/20080125155336/http://members.aol.com/cattrust/cheetah.htm. 
  6. ^ M Menotti-Raymond and S J O'Brien. "Dating the genetic bottleneck of the African cheetah." Proc Natl Acad Sci U S A. 1993 April 15; 90(8): 3172–3176.
  7. ^ S. Freilich, A.R. Hoelzel and S.R. Choudhury, Genetic diversity and population genetic structure in the South American sea lion (Otaria flavescens), Department of Anthropology and School of Biological & Biomedical Sciences, University of Durham,U.K.
  8. ^ a b D. A. Gilbert, C. Packer, A. E. Pusey, J. C. Stephens, and S. J. O'Brien, Analytical DNA Fingerprinting in Lions: Parentage, Genetic Diversity, and Kinship, Journal of Heredity 1991;82:378-386; 0022-1503/91/, oxfordjournals.org.
  9. ^ Claes Ramel, Biodiversity and intraspecific genetic variation, Pure & Appl. Chem., Vol. 70, No. 11, pp. 2079-2084, 1998., iupac.org/.
  10. ^ How to compute and inbreeding coefficient (the path method), Braque du Bourbonnais.
  11. ^ Knud Christensen, 4.5 Calculation of inbreeding and relationship, the tabular method, in 14. Genetic calculation applets and other programs .
  12. ^ a b c Douglas Tave; Food and Agriculture Organization of the United Nations (1999). Inbreeding and brood stock management. Food & Agriculture Org.. pp. 50. ISBN 9789251043400. http://books.google.com/books?id=UdvIpkQOf5MC. 
  13. ^ G2036 Culling the Commercial Cow Herd: BIF Fact Sheet, MU Extension
  14. ^ "Genetic Evaluation Results". Archived from the original on August 27, 2001. http://web.archive.org/web/20010827074038/http://aipl.arsusda.gov/main/data.html. 
  15. ^ Homepage: S1008
  16. ^ Vogt, Dale; Swartz, Helen A.; Massey, John (October 1993). "Inbreeding: Its Meaning, Uses and Effects on Farm Animals". MU Extension. University of Missouri. http://extension.missouri.edu/publications/DisplayPub.aspx?P=G2911. Retrieved April 30, 2011. 
  17. ^ Top Cat Breeds for 2004
  18. ^ Preserving Quality and Genetic Diversity in a Dog Breed
  19. ^ http://www.perthnow.com.au/kissing-cousins-ok/story-fna7dq6e-1111116504749
  20. ^ Kingston H M, "ABC of Clinical Genetics", Page 7, 3rd Edition (2002), BMJ Books, London, 0-7279-1627-0
  21. ^ Bittles, A.H. (2001). "A Background Background Summary of Consaguineous marriage". consang.net. http://www.consang.net/images/d/dd/01AHBWeb3.pdf. Retrieved 2010 , citing Bittles, A.H.; Neel, J.V. (1994). "The costs of human inbreeding and their implications for variation at the DNA level". Nature Genetics 8 (8): 117–121. doi:10.1038/ng1094-117. PMID 7842008. 
  22. ^ "Caroline Seawright, "Women in Ancient Egypt, Women and Law"". http://www.thekeep.org/~kunoichi/kunoichi/themestream/women_egypt.html. 
  23. ^ "E.R. Bevan, "The House of Ptolomey"". http://penelope.uchicago.edu/Thayer/E/Gazetteer/Places/Africa/Egypt/_Texts/BEVHOP/13*.html. 
  24. ^ "The Habsburg Lip", Topics in the History of Genetics and Molecular Biology, Fall 2000
  25. ^ "The Imperial House of Habsburg: Chapter 5. Web page accessed September 23, 2007". Archived from the original on August 27, 2007. http://web.archive.org/web/20070827044244/http://www.hapsburg.com/menu5.htm. 
  26. ^ "The Role of Inbreeding in the Extinction of a European Royal Dynasty". http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005174. 
  27. ^ Stephen Lock; John M. Last; George Dunea (2001). The Oxford illustrated companion to medicine. Oxford University Press US. p. 329. ISBN 9780192629500. http://books.google.com/books?id=ORyJr1P7uGgC. 
  28. ^ David Bainbridge (2004). The X in Sex: How the X Chromosome Controls Our Lives. Harvard University Press. p. 88. ISBN 9780674016217. http://books.google.com/books?id=4zd4c1c3cQUC. 
  29. ^ Iceland's 'Kissing Cousins' Breed More Kids
  30. ^ An Association Between the Kinship and Fertility of Human Couples, Science, The Science Creative Quarterly (2008), 391: 813-816

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